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IL12B — TGFB2
Text-mined interactions from Literome
Zhou et al., Nat Immunol 2007
:
T helper cells that produce interleukin 17 ( IL-17 ; ` T ( H ) -17 cells ' ) are a distinct subset of proinflammatory cells whose in vivo function requires
IL-23 but whose in vitro differentiation
requires only IL-6 and
transforming growth factor-beta ( TGF-beta )
Dey et al., Scand J Immunol 2007
(Leishmaniasis, Visceral) :
These chemokines induced the known pro-inflammatory cytokine
interleukin (IL)-12 secretion and
inhibited the secretion of anti-inflammatory cytokines IL-10 and
transforming growth factor-beta in infected macrophages
de Beaucoudrey et al., J Exp Med 2008
(Genetic Diseases, Inborn) :
We addressed the question of the development of human IL-17 -- producing T helper cells in vivo by quantifying the production and secretion of IL-17 by fresh T cells ex vivo, and by T cell blasts expanded in vitro from patients with particular genetic traits affecting
transforming growth factor ( TGF ) beta , IL-1, IL-6, or
IL-23 responses
Annunziato et al., Blood 2009
(Autoimmune Diseases) :
While murine Th17 cells develop in response to IL-6, IL-1, and
transforming growth factor ( TGF ) -beta , human Th17 cells originate from these CD161 ( + ) precursors in
response to IL-1beta and
IL-23 , the need for TGF-beta being controversial
Zhang et al., Clin Neurol Neurosurg 2010
(Autoimmune Diseases...) :
IFNbeta inhibited IL-1beta, IL-23 and
transforming growth factor ( TGF ) -beta ( which induce Th17 cell differentiation ), and
induced IL-27,
IL-12p35 and IL-10 ( which suppress it ) in dendritic cells (DCs) and B-cells
Ye et al., J Leukoc Biol 1995
:
Furthermore, both
transforming growth factor-beta and genistein, a tyrosine kinase inhibitor, could
suppress IL-2 and
IL-12 signaling but CsA was generally inactive
Fulton et al., J Infect Dis 1998
:
Regulation of
interleukin (IL)-12 production by coexpression of tumor necrosis factor (TNF)-alpha, IL-10, and
transforming growth factor ( TGF ) -beta in human monocytes infected with Mycobacterium tuberculosis H37Ra was analyzed
Yasuda et al., J Clin Invest 1998
(Diabetes Mellitus, Type 1) :
Reverse transcription-PCR analysis revealed that local production of
IL-12p40 led to the decrease of interferon-gamma and the augmentation of
transforming growth factor-beta at the graft site