Gene interactions and pathways from curated databases and text-mining

◀ Back to CXCL12

CXCL12 — IL17A

Text-mined interactions from Literome

Rahman et al., Clin Immunol 2005 : IL-17R activation of human airway smooth muscle cells induces CXCL-8 production via a transcriptional dependent mechanism ... While it has been shown that IL-17 induces expression of the CXC chemokines in the airways leading to neutrophil recruitment, the IL-17R expression in human ASM cells and the molecular mechanism by which IL-17 mediates neutrophilic chemo-attractant CXCL-8 ( IL-8 ) production have not been determined ... Furthermore, IL-17 induction of CXCL-8 mRNA and protein release from ASM cells was abrogated by transcriptional inhibitor actinomycin D. CXCL-8 promoter reporter analysis using wild type and site specific mutant constructs demonstrated a key role for AP1 and NF-kappaB binding sites in IL-17 induced CXCL-8 expression ... These data demonstrate that IL-17 mediates CXCL-8 expression in ASM cells via a transcriptional mechanism depending on NF-kappaB and AP-1 pathways
Dragon et al., Am J Physiol Lung Cell Mol Physiol 2007 : IL-17 enhances IL-1beta mediated CXCL-8 release from human airway smooth muscle cells ... In this study, we evaluated whether IL-17 could enhance IL-1beta mediated CXCL-8 release from human airway smooth muscle cells ( HASMC ) and investigated the upstream and downstream signaling events regulating the induction of CXCL-8
Kim et al., Arthritis Rheum 2007 (Arthritis, Rheumatoid) : This study was undertaken to investigate the effect of interleukin-17 (IL-17) and CD40-CD40L interaction on SDF-1 production in RA fibroblast-like synoviocytes ( FLS ) ... The production of SDF-1 in RA FLS was enhanced by IL-17 stimulation ... When FLS were cocultured with T cells, SDF-1 production was up-regulated, especially in the presence of IL-17 , but FLS were inhibited by neutralizing anti-IL-17 and anti-CD40L antibodies
Lee et al., J Immunol 2008 : IL-17 strongly repressed TNF-alpha stimulated expression of CXCL10, CXCL11, and CCL5, but synergized with TNF-alpha for induction of CXCL8 , CXCL1, and CCL20 mRNAs ... In contrast, IL-17 represses expression of CXCL10, CXCL11 , and CCR5, three chemokines that selectively recruit Th1 but not other effector T cells
Chen et al., PloS one 2011 : IL-17A significantly enhanced the production of CXCL8 , CCL2, CCL20 and IL-6 by these cells
Takahashi et al., Eur J Oral Sci 2011 : We evaluated the effects of IL-17 on the expression of CXCL8 and CCL2 by HGECs using quantitative real-time PCR and ELISA ... Stimulation with IL-17 up-regulated the secretion of CXCL8 protein, but not the secretion of CCL2 protein ... The effect of IL-17 on CXCL8 production was suppressed using an anti-IL-17R Ig, suggesting a role for a specific receptor-ligand interaction ... In conclusion, IL-17 is involved in the regulation of the innate immune response in HGECs by inducing CXCL8 production
Li et al., Cell Immunol 2013 (Graves Disease) : These changes facilitate the IL-17 mediated upregulation of IL-6, CXCL10 , and ICAM-1
Al-Alwan et al., J Immunol 2013 (Airway Remodeling...) : Previously, we established that IL-17 induced ( CXCL1, CXCL2 , and CXCL3 ) production promoted airway smooth muscle cell ( ASMC ) migration, and consequently we sought to investigate the molecular mechanism of CXC induced ASMC migration