Gene interactions and pathways from curated databases and text-mining

◀ Back to IL2

IL18 — IL2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Liu et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 1997 (Yang Deficiency) : Hemorheological indexes, brain noradrenaline ( NE ), adrenocorticotropine ( ACTH ), beta endorphin, cortisol, estradiol, testosterone, interleukin-II (IL-2), tumour necrosis factor (TNF) in the blood, and rat spleen 's lymphocyte transformation and induction of IL-2 and the activity of natural killer cells ( NKC )
Song et al., Neuroscience 1999 : As well, interleukin-6 and interleukin-2 were both found to reduce the homovanillic acid response associated with the stress, and interleukin-2 promoted a decline of homovanillic acid levels
Greene et al., Biochim Biophys Acta 1999 : Interleukin-1 receptor associated kinase and TRAF-6 mediate the transcriptional regulation of interleukin-2 by interleukin-1 via NFkappaB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA
Kohka et al., J Immunol 2000 : Histamine ( 10-7 to 10-4 M ) concentration-dependently stimulated the production of IL-18 and IFN-gamma and inhibited the production of IL-2 and IL-10 in human PBMCs. Histamine in the same concentration range did not induce the production of IL-12 at all
Greene et al., J Immunol 2000 (Sarcoidosis, Pulmonary) : We investigated the role of IL-18 in IL-2 expression in sarcoidosis ... Addition of IL-18 to normal ELF also induced IL-2 mRNA accumulation, whereas correspondent depletion of IL-18 from sarcoid ELF using neutralizing Abs abrogated all of the effects
Matsuura et al., Dig Liver Dis 2000 (Crohn Disease) : The effect of interleukin-4 on lamina propria mononuclear cells from Crohn 's disease, ulcerative colitis and control mucosa was assessed on various T-cell functions : interleukin-2 induced cytotoxicity, soluble interleukin-2 receptor and interleukin-2 production, and expression of mRNA for interleukin-2R and interferon-gamma
Ju et al., Gene Ther 2000 (Melanoma, Experimental) : IL-18 gene transfer could significantly augment the cytotoxicity of NK cells and macrophages, and increase the production of interleukin-2 and interferon-gamma, as compared with treatments with AdCD/5FC, AdlacZ/5FC or PBS
Kanai et al., Gastroenterology 2000 (Crohn Disease) : IL-18 up-regulated IL-2 receptor expression in mucosal lymphocytes from patients with CD, but not from normal controls
Kelley et al., Lipids 2001 : CLA supplementation did not alter the in vitro secretion of prostaglandin E2, leukotriene B4, interleukin-1beta (IL-1beta), or tumor necrosis factor alpha (TNFalpha) by PBMC simulated with lipopolysaccharide, and the secretion of IL-2 by PBMC stimulated with phytohemagglutinin
Wald et al., Eur J Immunol 2001 : Interleukin-18 (IL-18) , a pleiotropic cytokine produced by activated macrophages, plays significant roles in the immune response, inducing the secretion of IFN-gamma, TNF-alpha and IL-2 , enhancing NK cell activity and potentiating the differentiation of Th1 cells
Okazawa et al., Am J Gastroenterol 2002 (Crohn Disease...) : The functional activity of IL- 12 and IL-18 was assessed by the effect of recombinant IL-12 and recombinant IL-18 on interferon-gamma production, the proliferative response, and the induction of IL-2R , IL-12R, and IL-18R of LPLs
Dalhoff et al., Lancet Infect Dis 2003 : In general, most fluoroquinolone derivatives superinduce in-vitro interleukin 2 synthesis but inhibit synthesis of interleukin 1 and tumour necrosis factor (TNF)alpha ; furthermore, they enhance significantly the synthesis of colony stimulating factors (CSF)
Chakir et al., Eur J Immunol 2003 : Furthermore, anti-CD3 induced IL-12/IL-18 responsiveness was fully abrogated in the presence of cyclosporin A whereas IL-2 induced IL-12/IL-18 responsiveness was not, reminiscent of the previously reported IL-12+IL-18 innate pathway of T cell activation
Rodriguez-Galán et al., J Immunol 2005 : In the periphery, IL-18 synergistically induces the expression of the Th1 cytokine IFN-gamma in the presence of IL-12 and the Th2 cytokines IL-5 and IL-13 in the presence of IL-2
Takahashi et al., Antimicrob Agents Chemother 2005 : In addition, ciprofloxacin suppressed the interleukin-18 induced production of tumor necrosis factor alpha, gamma interferon, and interleukin-12 in peripheral blood mononuclear cells by inhibiting the expression of intercellular adhesion molecule 1, B7.1, B7.2, and CD40 on monocytes, and this effect could be reversed by the addition of indomethacin or NS398
Fernández et al., Appl Environ Microbiol 2007 : Furthermore, expression of a mature mouse IL-2 gene resulted in interleukin secretion without the requirement for a leader sequence
Tomizawa et al., Clin Exp Immunol 1991 : Of the cytokines studied, interleukin-4 (IL-4) and interferon-gamma (IFN-gamma) were involved in the regulation of IL-2R on B cells
Mel'nichenko et al., Vopr Virusol 2011 (Herpesviridae Infections) : There were changes in the cytokine profile, activation of IFN-alpha, IL-2, IL-8, IL-10, and IL-18 gene expression, and suppression of IL-2 gene transcription in the majority of the patients
Scholz et al., Cell Signal 1989 (Leukemia) : Synergistic induction of interleukin 2 receptor ( TAC ) expression on YT cells by interleukin 1 or tumor necrosis factor alpha in combination with cAMP inducing agents
Schultzberg et al., Neuroscience 1989 : These antisera also inhibited stimulation of interleukin-2 receptor expression by purified human interleukin-1
Falk et al., Lymphokine Res 1989 : The cytokine interleukin-1 plays an important role in the induction of IL-2 secretion and IL-2 receptor expression
Lee et al., J Rheumatol 1985 (Arthritis...) : The low IL-2 levels was not a result of degradation or consumption of endogenously produced interleukin
Anastassakos et al., Clin Exp Immunol 1987 (Chronic Disease...) : To test the hypothesis that reduced lymphocyte transformation in response to PHA in chronic hepatitis B virus infection might be due to deficient lymphokine production, lymphocyte transformation was measured in the presence or absence of exogenous interleukin 1, interleukin 2 or both, or, as a source of mixed lymphokines, supernatants from mixed lymphocyte reactions
Uchiyama et al., Microbiol Immunol 1986 : T cells obtained by the nylon wool column method alone produced IL 2 on TSST-1 stimulation in the presence of either macrophages or a macrophage lysate containing interleukin 1
Mukaida et al., J Immunol 1987 (Leukemia) : Signal requirement for interleukin-1 dependent interleukin 2 production by a human leukemia derived HSB.2 subclone
Soulillou et al., Eur J Cancer Clin Oncol 1985 (Hodgkin Disease) : Peripheral blood lymphocytes ( PBL ) of patients with Hodgkin 's disease were studied for their capacity to produce interleukin 2 upon in vitro phytohemaglutinin stimulation in the presence or absence of either interleukin 1 or indomethacin ( 2 micrograms/ml ) ; eight patients were studied at the discovery of their disease before receiving any therapy ( onset HD ; OHD )
Solbach et al., Blood 1984 (Sezary Syndrome) : In this article we have studied the effects of the immunosuppressive drug cyclosporine A ( CsA ) on growth, interleukin-2 (IL-2) production, and the induction of IL-2 responsiveness of peripheral blood monocytes ( PBMs ) from five patients with Sézary 's syndrome in vitro, using the lectin phytohemagglutinin ( PHA ) and the phorbol ester phorbol myristate acetate ( PMA ) as stimuli
Knop et al., Hautarzt 1984 (Dermatitis, Atopic...) : The production of interleukin 2 is induced by interleukin 1, which can be also produced by keratinocytes ( epidermal T-cell activating factor, ETAF )
Bunjes et al., Eur J Immunol 1981 : The selective effects included a blockade of interleukin 2 release from activated T helper cells on the one hand and inhibition of interleukin 1 release from splenic adherent cells on the other
Hersey et al., J Immunol 1983 (Cell Transformation, Neoplastic...) : These supernatants did not inhibit interleukin 1 production, and also did not inhibit the mitogenic activity of performed IL 2 on IL 2-dependent target cells
Okada et al., Proc Natl Acad Sci U S A 1981 : In a clone ( 38-B ) that did not show any IL-2 activity in culture supernatants, the addition of macrophages induced IL-2 production in the presence of phytohemagglutinin, suggesting that interleukin-1 induced IL-2 production in T hybrid cells
Kees et al., J Immunol Methods 1994 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : A new human cell line for the molecular dissection of the requirement for interleukin-1 in the production of interleukin-2 by immature T cells
Armant et al., Eur J Immunol 1996 : Functional CD40 ligand expression on T lymphocytes in the absence of T cell receptor engagement : involvement in interleukin-2 induced interleukin-12 and interferon-gamma production
Micallef et al., Cancer Res 1997 (Sarcoma, Experimental) : In conclusion, IL-18 seems to enhance the generation of NK activity early after tumor transplantation and simultaneously induces an increase and a decrease in the production of IL-10 and IL-2 , respectively