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IL1B — TRAF6

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TRAF6 → IL1B (increases) Zirlik et al., Arterioscler Thromb Vasc Biol 2007*
  Evidence: Stimulation with IL-1 or TNF- induced expression of TRAF-1, -3, and -6 in ECs and SMCs, whereas neither stimulus affected the constitutive expression of TRAF-2 or -5 (Figure 1).
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → TRAF6 (TRAF6) (modification, collaborate) Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6 complex (IRAK1-TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4) (modification, collaborate)
  Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 complex (IL1B-IL1R1-IL1RAP-TICAM2-IRAK4) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, activates)
  Bin et al., J Biol Chem 2003
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: IL1B → TRAF6 (indirect_complex) Cao et al., Nature 1996
• Reactome Reaction: IL1B → TRAF6 (reaction) Gottipati et al., Cell Signal 2008, Cao et al., Nature 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: Complex of TRAF6-IL1B-IL1RAP (anti bait coimmunoprecipitation) Häcker et al., Nature 2006
• IRef Dip Interaction: Complex of TRAF3-TRAF6-IL1B-IL1RAP (anti bait coimmunoprecipitation) Häcker et al., Nature 2006

Text-mined interactions from Literome

Wu et al., Cell Signal 2009 : Furthermore, co-transfection study shows that HSP27 S78/82A, two phosphorylated serine site deficient mutants, but not wild-type HSP27 ( HSP27 WT ) and HSP27 S15A mutant increases TRAF6 ubiquitination and thereby mediates IL-1beta triggered IKK phosphorylation
Ahmad et al., J Immunol 2009 : The role and relative contribution of MyD88, IRAK1, and TRAF6 adaptor proteins in IL-1beta regulation of aggrecanase-1 ( ADAMTS-4 ) is unknown