Gene interactions and pathways from curated databases and text-mining

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IL1R1 — IL8

Text-mined interactions from Literome

Yuan et al., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2002 (Disease Models, Animal) : [ Effect of interleukin-1 on expression of interleukin-1 receptor in KM mice sciatic nerves before and after injuries ]
Dahlén et al., J Immunotoxicol 2008 (Arthritis, Experimental) : Interleukin-1 receptor antagonist ( IL-1Ra ) is a naturally occurring inhibitor of the pro-inflammatory interleukin-1 mediated activation of the interleukin-1 receptor (IL-1R)
Lee et al., Biochim Biophys Acta 2009 : DSCR1-1S also stimulated IL-1R mediated signaling pathways, TAK1 activation, NF-kappaB transactivation, and IL-8 production, all downstream consequences of IL-1R activation
Shemesh et al., Atherosclerosis 2012 (Aortic Diseases...) : Interleukin-1 receptor type-1 in non-hematopoietic cells is the target for the pro-atherogenic effects of interleukin-1 in apoE-deficient mice
Bonin et al., J Biol Chem 1988 : Modulation of interleukin-1 receptor expression and interleukin-1 response in fibroblasts by platelet derived growth factor
Heguy et al., J Biol Chem 1993 : A chimeric type II/type I interleukin-1 receptor can mediate interleukin-1 induction of gene expression in T cells
Marsh et al., J Immunol 1998 : Consistent with the identification of IL-1beta as the lymphocyte factor, fibroblast or mesangial cell IL-8 release induced by the IgG stimulated lymphocyte supernatants was inhibited by 1 ) the combination of IL-1R antagonist and soluble type II IL-1R , 2 ) an IL-1 converting enzyme inhibitor, or 3 ) anti-IL-1beta but not preimmune Abs