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IL2RA — TGFB1
Text-mined interactions from Literome
Wu et al., Zhonghua Yan Ke Za Zhi 2000
:
TGF - beta(1) significantly
inhibits the expression of CD(69) ( + ) and
CD(25) ( + ) in peripheral T cells induced by allo-corneal epithelial cells in vitro
Piccirillo et al., J Exp Med 2002
:
The
role of
TGF-beta1 in CD4 ( + )
CD25 ( + ) suppressor function remains unclear
Green et al., Proc Natl Acad Sci U S A 2003
(Diabetes Mellitus, Type 1) :
Here, we show by using a CD8+ T cell mediated model of type 1 diabetes that
transforming growth factor ( TGF ) -beta-TGF-beta receptor signals are
critical for
CD4+CD25+ Treg cell regulation of autoreactive islet-specific cytotoxic T lymphocytes
Veltkamp et al., Gut 2005
(Colitis) :
CD4+CD25+ but not CD4+CD25- cell transfer into BM -- > Tgepsilon26 mice reduced the number of tumour necrosis factor alpha+ CD4+ cells and
increased the secretion of
transforming growth factor beta by MLN cells
Kim et al., J Biol Chem 2005
:
Smad dependent cooperative
regulation of
interleukin 2 receptor alpha chain gene expression by T cell receptor and
transforming growth factor-beta
Kariminia et al., Infect Immun 2005
(Leishmaniasis, Mucocutaneous) :
Altogether our data demonstrated that
TGF-beta1 is
involved in the suppressive activity of L. guyanensis stimulated CD4 ( + )
CD25 ( + ) T cells from healthy controls
Luo et al., Proc Natl Acad Sci U S A 2007
(Diabetes Mellitus, Type 1) :
Here we show that beta-cell peptide pulsed dendritic cells (DCs) from nonobese diabetic ( NOD ) mice can effectively induce CD4 ( + )
CD25 ( + ) Foxp3 ( + ) T cells from naïve islet-specific CD4 ( + ) CD25 ( - ) T cells in the
presence of
TGF-beta1
Liu et al., Zhonghua Yi Xue Za Zhi 2007
:
( 1 ) The expression of CD25 is suppressed in a dose dependent manner when the T-lymphocytes are co-cultured with 10,000 MSCs or more, while 100 MSCs have no detectable effect ; ( 2 ) The suppression of CD25 can be lasted more than 96 hrs ; ( 3 ) The down regulation of CD25 is mediated by some soluble factors ; ( 4 ) The reduced expression of
CD25 caused by MSC inhibition is not
mediated by
TGF-beta1 and IL-10
Chaput et al., Gut 2009
(Adenocarcinoma...) :
Finally, interleukin 6 and
TGF beta 1 synergistically
induced the generation of CD8 ( + )
CD25 ( + ) Foxp3 ( + ) T cells ex vivo