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IL5 — LTB

Text-mined interactions from Literome

Rola-Pleszczynski et al., Union Med Can 1989 : In particular, LTB4 can induce suppressor cells, activate the synthesis and production of lymphokines such as interleukin 2 or interferon-gamma, stimulate the production of interleukin 1 by monocytes or macrophages, and activate cytotoxic cells against virus infected or tumor target cells
Matsumoto et al., Prostaglandins Leukot Essent Fatty Acids 1995 (Leukemia, Basophilic, Acute) : IL-3 and IL-5 enhance the production of LTB4 stimulated by calcium ionophore in rat basophilic leukemia cells ... These results suggest that IL-3 and IL-5 increase the production of LTB4 by priming the activity of phospholipase A2(PLA2) without inducing enzymes in the arachidonate 5-lipoxygenase pathway
Yamaoka et al., Eur J Immunol 1993 : In this study, we investigated whether LTB4 regulates IL-5 generation from human T cells and subsequently modulates eosinophil functions ... Preincubation of T cells with very low concentrations ( 10 ( -12 ) to 10 ( -8 ) M ) of LTB4 induced concentration dependent IL-5 production, the event occurring after the first 24 h of cultivation ... These data suggest that LTB4 induces bioactive IL-5 production from T cells and that the released IL-5 modulates eosinophil functions which might play a crucial role in eosinophil linked allergic inflammatory process