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IGF1 — IL8

Text-mined interactions from Literome

Remacle-Bonnet et al., Cancer Res 2000 (Adenocarcinoma...) : This was correlated with the weak ability of Fas ligation to enhance IL-8 production in the presence or absence of IGF-I
Satyamoorthy et al., Cell Growth Differ 2002 (Melanoma) : IGF-I overexpression induced IL-8 production in melanoma cells, especially in biologically early melanomas by accelerating its transcription rate via activation of mitogen activated protein kinase pathway
Garrouste et al., Cell Death Differ 2002 : Correspondingly, IGF-I markedly enhanced the TNF- and IFN/TNF induced NF-kappaB dependent interleukin-8 production ... Correspondingly, IGF-I markedly enhanced the TNF- and IFN/TNF induced NF-kappaB dependent interleukin-8 production
Kooijman et al., Cell Signal 2003 : IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal regulated protein kinase ... In the present study, we show that IGF-I stimulates IL-8 mRNA expression and IL-8 secretion in the leukemic cell line HL-60 ... Collectively, our results suggest that basal JNK activity and activation of the MEK-ERK pathway are required for upregulation of IL-8 by IGF-I in HL-60 cells
Kim et al., Biochem Biophys Res Commun 2004 (MAP Kinase Signaling System) : Furthermore, IGF-II remarkably increased the DNA binding activities of NF-kappaB and AP-1, and the IL-8 promoter activity
Méndez-Dávila et al., J Endocrinol Invest 2004 (Osteoporosis) : We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and interleukin-1 stimulated interleukin (IL)-6, transforming growth factor-beta1 ( TGF-beta1 ) and insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Kooijman et al., Int J Biochem Cell Biol 2006 : Insulin-like growth factor-I augments interleukin-8 promoter activity through induction of activator protein-1 complex formation ... We previously established that stimulation by IGF-I of interleukin (IL)-8 expression in leukocytes required activation of extracellular regulated kinase (ERK) and basal activity of c-Jun N-terminal kinase (JNK) ... These results indicate that IGF-I can augment IL-8 expression through activation of AP-1 independent of other inducible transcription factors which have shown to be involved in IL-8 regulation by immune stimuli ... This finding is in agreement with our previous observation that IGF-I is able to enhance basal IL-8 production in peripheral blood mononuclear cells ( PBMC ) in the absence of other stimuli
Kooijman et al., Growth Horm IGF Res 2007 (Inflammation...) : Regulation of interleukin-8 expression in human prostate cancer cells by insulin-like growth factor-I and inflammatory cytokines ... Since serum IGF-I levels are related to risks of prostate cancer and cytokines like interleukin (IL)-6 and IL-8 have been implicated in prostate cancer progression, we investigated the effects of IGF-I on IL-6 and IL-8 expression in the prostate cancer cell ... We found that IGF-I stimulates IL-8 mRNA expression and secretion in DU-145 cells, whereas the secretion of IL-6 was hardly affected ... IGF-I enhances IL-8 expression in synergy with IL-1beta, but not with tumour necrosis factor (TNF)alpha ... Our results indicate that IGF-I stimulates IL-8 expression through the MEK-ERK pathway in DU-145 cells, at least in part, by augmentation of transcriptional activity
Haleagrahara et al., International journal of molecular sciences 2011 : The present study was aimed to evaluate the effects of IGF-1 on circulating level of angiogenic cytokine interleukin-8 (IL-8) , in experimentally induced myocardial ischemia in rats
Glazebrook et al., J Vasc Res 1998 : Regulation of insulin-like growth factor-1 expression in vascular endothelial cells by the inflammatory cytokine interleukin-1