◀ Back to IL4
IL4 — INS
Text-mined interactions from Literome
Chang et al., J Biol Chem 2000
(Burkitt Lymphoma...) :
IL-4 also
triggers phosphorylation of
insulin receptor substrate (IRS) , leading to stimulation of cell growth
Mabley et al., Br J Pharmacol 2001
(Diabetes Mellitus, Experimental) :
In vitro the cytokine combination
; interleukin-1beta , tumor necrosis factor-alpha and interferon-gamma
inhibited glucose stimulated
insulin secretion from isolated rat islets of Langerhans and decreased RIN-5F cell viability
Das et al., J Assoc Physicians India 2003
(Cardiomyopathies...) :
Conversely,
insulin suppresses production of MIF, TNF-alpha, IL-1, IL-6, and free radicals, enhances endothelial NO generation, and
enhances the production of anti-inflammatory cytokines
IL-4 , and IL-10, corrects stress hyperglycemia and improves myocardial function
Jeschke et al., Endocrinology 2004
(Endotoxemia) :
In addition,
insulin increased antiinflammatory cytokine expression in the liver ; serum levels of IL-2,
IL-4 , and IL-10 ; and hepatic suppressor of cytokine signaling-3 mRNA expression
Rabinovitch et al., Diabetologia 1992
:
The individual cytokines,
interleukin 1 ( 1 U/ml ), tumour necrosis factor ( 10 ( 2 ) U/ml ), and interferon gamma ( 10 ( 2 ) U/ml )
inhibited insulin release but did not increase islet malondialdehyde levels
Fain et al., Metabolism 2005
:
Insulin enhances vascular endothelial growth factor,
interleukin-8 , and plasminogen activator inhibitor 1 but not interleukin-6 release by human adipocytes
Yelich et al., Pancreas 1992
:
Effects of endotoxin and
interleukin-1 on glucagon and
insulin secretion from the perfused rat pancreas
Faresjö et al., Diabetes Metab Res Rev 2006
(Diabetes Mellitus, Type 1) :
Fasting C-peptide levels at diagnosis correlated with
insulin induced IFN-gamma ( R = 0.52 ; p = 0.05 ) and negatively with spontaneous
IL-4 secretion ( R = -0.62 ; p < 0.05 )
Zawalich et al., Mol Cell Endocrinol 1991
:
Influence of staurosporine, nitrendipine and monooleoylglycerol on
interleukin-1 induced
insulin secretion and phosphoinositide hydrolysis
Johannesen et al., Acta Endocrinol (Copenh) 1990
:
During beta-cell stimulation with tolbutamide,
interleukin 1 beta
caused inhibition of
insulin accumulation to 36 +/- 9 % of control
Sommese et al., Inflammopharmacology 1998
:
Insulin regulates IL-1alpha, Ifn-y and
IL-4 release from murine splenocytes stimulated with staphylococcal protein A, toxic shock syndrome toxin-1 and streptococcal lysin S
Shimizu et al., J Endocrinol Invest 1991
:
Involvement of
interleukin-1 in the inhibition of in vivo
insulin release : possible role of adrenal glands
Uehara et al., Eur J Pharmacol 1991
(Hyperinsulinism) :
With the aim of studying the mechanism by which peripherally injected
interleukin-1 increases the serum levels of
insulin in conscious rats, the effects of indomethacin, a cyclooxygenase inhibitor, on interleukin-1 induced hyperinsulinemia were examined using male Wistar rats implanted with intra-atrial cannulas ... It was also found that this
insulin response to
interleukin-1 was dose related ... Pretreatment with indomethacin ( 3 mg/kg body weight ), however, completely blocked the
interleukin-1 induced stimulation of
insulin secretion
Chen et al., Nat Med 2012
(Helminthiasis, Animal...) :
We found that IL-17 initially contributed to inflammation and lung damage, whereas subsequent
IL-4 receptor (IL-4R) signaling reduced elevations in IL-17 mRNA levels,
enhanced the expression of
insulin-like growth factor 1 (IGF-1) and IL-10 and stimulated the development of M2 macrophages, all of which contributed to the rapid resolution of tissue damage
Parazzoli et al., J Biol Chem 2012
:
Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for
interleukin-1ß induced prostaglandin E2 production and inhibition of
insulin secretion in pancreatic islets
Helqvist et al., Acta Endocrinol (Copenh) 1989
:
Treatment with 10 mumol/l of verapamil ( a potent blocker of the voltage dependent calcium channel ) tended to suppress the inhibitory
effect of
interleukin 1 on
insulin release from rat islets, suggesting protection against cytotoxicity
Hansen et al., Biomed Biochim Acta 1988
:
Effect of
interleukin-1 on the biosynthesis of proinsulin and
insulin in isolated rat pancreatic islets
Sandler et al., Endocrinology 1987
:
Inhibitory
effects of
interleukin 1 on
insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets
Rabinovitch et al., Diabetologia 1994
:
The individual cytokines,
interleukin 1 ( 10 U/ml ), tumour recrosis factor ( 10 ( 3 ) U/ml ) and interferon gamma ( 10 ( 3 ) U/ml )
inhibited insulin release from rat islets, but did not cause DNA fragmentation or destroy islet cells ; by contrast, combination of the three cytokines induced DNA fragmentation and islet-cell death
Galdiero et al., Eur Cytokine Netw 1995
:
Effect of growth hormone, prolactin and
insulin on the release of IL-1 alpha, IFN-gamma and
IL-4 by staphylococcal enterotoxin A-stimulated splenocytes