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INS — PTGS2

Text-mined interactions from Literome

Persaud et al., Diabetes 2007 (Cadaver) : Perifusion experiments with human islets indicated that PLA(2) inhibition inhibited glucose stimulated insulin secretion, whereas inhibitors of COX-2 and 12-LOX enzymes enhanced basal insulin secretion and also secretory responses induced by 20 mmol/l glucose or by 50 mumol/l arachidonic acid
Martins et al., Cell Physiol Biochem 2008 : In the present study, we investigated the effect of insulin on the LPS induced production of nitric oxide ( NO ) and prostaglandin ( PG ) -E ( 2 ), on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 , and on nuclear factor kappa B (NF-kappaB) activation in AMs
Collino et al., Diabetes 2009 (Body Weight...) : At 24 h of reperfusion, TDZD-8 and insulin significantly reduced plasma levels of tumor necrosis factor-alpha ; neutrophil infiltration, measured as myeloperoxidase activity and intercellular-adhesion-molecule-1 expression ; and cyclooxygenase-2 and inducible-NO-synthase expression
Parazzoli et al., J Biol Chem 2012 : IL-1ß inhibited glucose stimulated insulin secretion equally in both WT and mPGES-1 ( -/- ) islets, indicating that COX-2 , not mPGES-1, mediates IL-1ß induced PGE ( 2 ) production and subsequent inhibition of insulin secretion
Guan et al., Am J Physiol 1998 : We demonstrate that both insulin and IGF-I increase IL-1 beta induced Cox-2 and iNOS protein expression, which in turn enhance PGE2 and NO production