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IRAK1 — IRF6

Text-mined interactions from Literome

Yamashina et al., Biochem Biophys Res Commun 2000 : In Kupffer cells from mice treated with ethanol 1 h earlier, LPS induced TNFalpha production, and IRAK expression and activity and NFkappaB were decreased 50-60 % of control
Ferlito et al., J Leukoc Biol 2001 (Leukemia, Monocytic, Acute...) : LPS stimulation induced production of TNF-alpha or TxB2 and degradation of IRAK
Bannerman et al., J Biol Chem 2002 : Using a variety of dominant negative constructs, we have identified a role for MyD88 and interleukin-1 receptor associated kinase-1 ( IRAK-1 ) in mediating LPS pro-apoptotic signaling in human endothelial cells
Taggart et al., J Biol Chem 2002 : We have also demonstrated that SLPI prevents LPS induced interleukin-1 receptor associated kinase and IkappaBbeta degradation
Sato et al., Int Immunol 2002 : In contrast, mycoplasmal lipopeptides did not affect the MyD88 independent pathway, but impaired the MyD88 dependent signaling by inhibiting LPS mediated activation of IL-1 receptor associated kinase (IRAK) 1
Medvedev et al., J Immunol 2002 : LPS induced the association of MyD88 with TLR4 and increased IRAK-1 activity in medium pretreated cells ... In LPS-tolerant monocytes, however, MyD88 failed to be recruited to TLR4, and IRAK-1 was not activated in response to LPS stimulation ... Moreover, endotoxin-tolerant CHO cells that overexpress human TLR4 and MD-2 also showed decreased IRAK-1 kinase activity in response to LPS despite the failure of LPS to inhibit cell surface expression of transfected TLR4 and MD-2 proteins
Ferlito et al., J Endotoxin Res 2002 : Neither PTx nor PP2 inhibited LPS induced activation of interleukin receptor activated kinase ( IRAK ) or inhibited translocation of NF-kappaB
Yamashina et al., Nihon Arukoru Yakubutsu Igakkai Zasshi 2003 (Liver Diseases, Alcoholic) : In contrast, in Kupffer cells from mice treated with ethanol 21 hours earlier, LPS induced TNF alpha production, expression and activity of IRAK were increased 1.5-fold over controls, while NF kappa B activation was elevated 3-fold
Asehnoune et al., J Immunol 2004 : Activation of IL-1R associated kinase-1 (IRAK-1) and IRAK-4 in response to LPS stimulation was inhibited by antioxidants
Noubir et al., J Biol Chem 2004 : Lipopolysaccharide (LPS) signaling leading to nuclear factor-kappaB activation in mononuclear phagocytes involves interleukin-1 receptor associated kinase ( IRAK ), which is rapidly activated after exposure to agonist
Cuschieri et al., Cell Immunol 2004 : LPS stimulation led to the phosphorylation and degradation of IRAK , followed by activation of JNK/SAPK, ERK 1/2, and p38 ... Proteasome inhibition with either lactacystin or MG-132 attenuated LPS induced IRAK degradation, and enhanced activation of JNK/SAPK, ERK 1/2, and p38
Frost et al., Am J Physiol Cell Physiol 2004 (MAP Kinase Signaling System) : LPS transiently stimulated the phosphorylation of the interleukin-1 receptor associated kinase ( IRAK-1 ) in C ( 2 ) C ( 12 ) cells and decreased the total amount of IRAK-1 both in vitro and in vivo over time
Cuschieri et al., J Surg Res 2004 : LPS stimulation led to the mobilization of TLR4 to lipid rafts followed by phosphorylation and activation of IRAK , ERK 1/2, p38, and JNK/SAPK
Li et al., J Leukoc Biol 2006 : Furthermore, decreased MyD88-IRAK immunocomplex formation, as demonstrated by immunoprecipitation, was observed in BLP-tolerant cells following a second BLP or LPS stimulation
Zhande et al., Mol Cell Biol 2007 : LPS stimulation increases IRAK1-FADD interaction and recruitment of the IRAK1-FADD complex to activated MyD88
Sebai et al., Arch Biochem Biophys 2010 : LPS increased CD14 expression ; IRAK1 and a phosphorylated form of p38 MAPK protein ... LPS increased CD14 expression ; IRAK1 and a phosphorylated form of p38 MAPK protein
Into et al., Cell Immunol 2010 (Bacterial Infections...) : LL-37 potently suppressed LPS induced gene expression of IL6, IL8 and CXCL10 and intracellular signaling events, degradation of IRAK-1 and IkappaBalpha and phosphorylation of p38 MAPK and IRF3, indicating that the LPS neutralizing activity is also exerted in HGFs. LL-37 also suppressed the expression of IL6, IL8 and CXCL10 induced by the TLR3 ligand poly ( I:C )
Sano et al., HPB (Oxford) 2010 (Disease Models, Animal...) : Phosphorylated IRAK-1 was suppressed by LPS , whereas no difference was observed in phosphorylated Akt
Reis et al., Cell Biochem Biophys 2011 : TNF-a is induced by LPS in the LMP knockout macrophages because I?B and IRAK are degraded normally via the MyD88 pathway
Liu et al., J Biol Chem 2012 : LPS increased TRAF6 autoubiquitination and binding to IRAK1
Kim et al., J Biol Chem 2012 (MAP Kinase Signaling System) : Pellino 2 ( but not Pellino 1 ) knockdown abolished IL-1- and LPS induced Lys-63 linked IRAK1 ubiquitination with reduced Lys-48 linked IRAK1 ubiquitination
Lee et al., J Agric Food Chem 2012 (Colitis...) : Ginsenoside Re also inhibited IRAK-1 phosphorylation induced by LPS , as well as IRAK-1 and IRAK-4 degradations in LPS stimulated peritoneal macrophages
Chong et al., J Surg Res 2012 : LPS dramatically increased protein expression of myeloid differentiation factor 88 and IRAK1 , and stimulated nuclear translocation of nuclear factor ?B, leading to an increases of gene expression and protein production of tumor necrosis factor a and interleukin-6
Joh et al., Cell Immunol 2012 (Inflammation) : Based on these findings, kalopanaxsaponin B ameliorates LPS induced systemic inflammation by inhibiting IRAK1 kinase
Hyam et al., Eur J Pharmacol 2013 : Arctigenin inhibited LPS induced PI3K, AKT and IKKß phosphorylation, but did not suppress LPS induced IRAK-1 phosphorylation
Olivieri et al., Free Radic Biol Med 2013 (Inflammation) : However, short-term CoQ10H2 supplementation attenuated LPS induced MIRAKIL changes in young cells ; in senescent cells CoQ10H2 supplementation significantly attenuated LPS induced miR-146a and IRAK-1 modulation but failed to curb IL-6 release