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IL1R1 — IRAK3

Pathways - manually collected, often from reviews:

• BioCarta signal transduction through il1r: IRAKs (IRAK3/IRAK1/IRAK2) → IL-1R (IL1R1) (modification, collaborate)
• BioCarta signal transduction through il1r: IRAKs (IRAK3/IRAK1/IRAK2) → IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  
• BioCarta signal transduction through il1r: TOLLIP → IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  
• BioCarta signal transduction through il1r: IL-1-alpha (IL1A) → IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  
• BioCarta signal transduction through il1r: MYD88 → IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  
• BioCarta signal transduction through il1r: IL-1RAcP (IL1RAP) → IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  
• BioCarta signal transduction through il1r: IL-1RA (IL1RN) → IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, inhibits)
  
• BioCarta signal transduction through il1r: IL-1R (IL1R1) → IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  
• BioCarta signal transduction through il1r: IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → TRAF6 (modification, activates)
• BioCarta signal transduction through il1r: IRAKs (IRAK3/IRAK1/IRAK2) → IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  
• BioCarta signal transduction through il1r: IRAKs (IRAK3/IRAK1/IRAK2) → IL-1R (IL1R1) (modification, collaborate)
• BioCarta signal transduction through il1r: TOLLIP → IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  
• BioCarta signal transduction through il1r: MYD88 → IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  
• BioCarta signal transduction through il1r: IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → IL-1RAcP (IL1RAP) (modification, collaborate)
• BioCarta signal transduction through il1r: IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → IL-1-beta (IL1B) (modification, collaborate)
• BioCarta signal transduction through il1r: IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → IL-1R (IL1R1) (modification, collaborate)
• KEGG Apoptosis: IL1R1/IL1RAP → Complex of IRAK1-IRAK2-IRAK3-IRAK4-MYD88 (protein-protein, activation)
  
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4) → IRAKM (IRAK3) (modification, collaborate) Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IRAKM (IRAK3) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) (modification, inhibits)
  Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species