Gene interactions and pathways from curated databases and text-mining

◀ Back to TLR9

IRF5 — TLR9

Text-mined interactions from Literome

Takaoka et al., Nature 2005 (Inflammation...) : We also provide evidence that IRF-5 interacts with and is activated by MyD88 and TRAF6, and that TLR activation results in the nuclear translocation of IRF-5 to activate cytokine gene transcription
Guo et al., J Immunol 2005 : This study illustrates the crucial roles for AP-1, IRF-1 , IRF-2, and STAT1 in the regulation of murine TLR9 expression
Atzei et al., J Biol Chem 2010 : We now describe the first functional characterization of the human ortholog of Cactin ( hCactin ) and show that it acts as a negative regulator of TLRs. Overexpression of hCactin suppresses TLR induced activation of NF-?B and interferon-regulatory factor transcription factors and induction of TLR-responsive genes, whereas knockdown of endogenous hCactin augments TLR induction of these responses
Fang et al., Genes Immun 2012 : IRF-5 is a transcription factor activated by toll like receptor (TLR)7 and TLR9 during innate immune responses