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IRF5 — TLR9
Text-mined interactions from Literome
Takaoka et al., Nature 2005
(Inflammation...) :
We also provide evidence that
IRF-5 interacts with and is
activated by MyD88 and TRAF6, and that
TLR activation results in the nuclear translocation of IRF-5 to activate cytokine gene transcription
Guo et al., J Immunol 2005
:
This study illustrates the crucial
roles for AP-1,
IRF-1 , IRF-2, and STAT1 in the regulation of murine
TLR9 expression
Atzei et al., J Biol Chem 2010
:
We now describe the first functional characterization of the human ortholog of Cactin ( hCactin ) and show that it acts as a negative regulator of TLRs. Overexpression of hCactin suppresses
TLR induced
activation of NF-?B and
interferon-regulatory factor transcription factors and induction of TLR-responsive genes, whereas knockdown of endogenous hCactin augments TLR induction of these responses
Fang et al., Genes Immun 2012
:
IRF-5 is a transcription factor
activated by toll like receptor (TLR)7 and
TLR9 during innate immune responses