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IRF7 — TLR1
Text-mined interactions from Literome
Guiducci et al., J Exp Med 2008
:
PI3K is critical for the nuclear translocation of
IRF-7 and type I IFN production by human plasmacytoid predendritic cells in
response to
TLR activation
Atzei et al., J Biol Chem 2010
:
We now describe the first functional characterization of the human ortholog of Cactin ( hCactin ) and show that it acts as a negative regulator of TLRs. Overexpression of hCactin suppresses
TLR induced
activation of NF-?B and
interferon-regulatory factor transcription factors and induction of TLR-responsive genes, whereas knockdown of endogenous hCactin augments TLR induction of these responses
Sisirak et al., Int J Cancer 2013
(Breast Neoplasms) :
Mechanisms of type I IFN inhibition did not involve
TLR downregulation but the
inhibition of
IRF-7 expression and nuclear translocation in pDC after their exposure to tumor derived supernatants or recombinant TGF-ß1 and TNF-a