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IRF7 — TNF
Text-mined interactions from Literome
Witcher et al., Blood 2004
(Leukemia, Promyelocytic, Acute) :
Although
IRF-7 was
up-regulated by
TNF and RA in all cells tested, expression of c-jun and PU.1 correlated with monocytic differentiation
Schoenemeyer et al., J Biol Chem 2005
:
We also demonstrate that MyD88, interleukin 1 receptor associated kinase 1, and
tumor necrosis factor receptor associated factor 6 are
required for the activation of IRF5 and
IRF7 in the TLR7 signaling pathway
Matikainen et al., J Virol 2006
:
IFN-alpha and
TNF-alpha induced the expression of the RIG-I, TLR3, MyD88, TRIF, and
IRF7 genes, whereas no detectable TLR7 and TLR8 was seen in A549 cells
Bennett et al., Blood 2006
(Inflammation...) :
Thus, knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents
IFNgamma/tumor necrosis factor alpha (TNFalpha) induced PKR activation and eIF2alpha phosphorylation, IkappaB degradation,
IRF-1 expression, and STAT1 phosphorylation, resulting in enhanced murine embryonic fibroblast (MEF) cell survival
Paun et al., J Biol Chem 2008
(Newcastle Disease) :
In addition,
IRF-5 regulates
TNFalpha but not type I interferon gene transcription in Newcastle disease virus infected peritoneal macrophages