Gene interactions and pathways from curated databases and text-mining

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IRF7 — TNF

Text-mined interactions from Literome

Witcher et al., Blood 2004 (Leukemia, Promyelocytic, Acute) : Although IRF-7 was up-regulated by TNF and RA in all cells tested, expression of c-jun and PU.1 correlated with monocytic differentiation
Schoenemeyer et al., J Biol Chem 2005 : We also demonstrate that MyD88, interleukin 1 receptor associated kinase 1, and tumor necrosis factor receptor associated factor 6 are required for the activation of IRF5 and IRF7 in the TLR7 signaling pathway
Matikainen et al., J Virol 2006 : IFN-alpha and TNF-alpha induced the expression of the RIG-I, TLR3, MyD88, TRIF, and IRF7 genes, whereas no detectable TLR7 and TLR8 was seen in A549 cells
Bennett et al., Blood 2006 (Inflammation...) : Thus, knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents IFNgamma/tumor necrosis factor alpha (TNFalpha) induced PKR activation and eIF2alpha phosphorylation, IkappaB degradation, IRF-1 expression, and STAT1 phosphorylation, resulting in enhanced murine embryonic fibroblast (MEF) cell survival
Paun et al., J Biol Chem 2008 (Newcastle Disease) : In addition, IRF-5 regulates TNFalpha but not type I interferon gene transcription in Newcastle disease virus infected peritoneal macrophages