Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
PTK2
→
Complex of ITGA10-ITGB1
(increases, ITGA10/ITGB1 Activity, PTK2 Activity)
Evidence: The expression and action of integrins are predominantly localized to the focal adhesion complex as originally demonstrated in fibroblasts. Focal adhesion complexes are the structural connection between the ECM and the cytoskeleton. Here, transmembrane signaling is mediated by integrins that cluster with dozens of cytoskeletal proteins and signaling molecules. Interestingly, integrins not only convey signals from the ECM into the cell (outside-in), but also react to cytoplasmic alterations by al...