Gene interactions and pathways from curated databases and text-mining

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F2 — ITGB3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of F2-ITGAV-ITGB3 → VEGFA (increases)
    Evidence: Our results show that VEGF can induce activation of the key integrins involved in angiogenesis, thereby establishing a mechanism by which the VEGF/VEGFR system can regulate cellular adhesive and migratory responses. Prothrombin, recently identified as an activation- dependent ligand of aVb3 (Byzova and Plow, 1998), supported limited adhesion of nonstimulated HUVECs; however, when these cells were stimulated with as little as 10 ng/ml VEGF165, adhesion to prothrombin increased by more than 10-fol...
  • OpenBEL Selventa BEL large corpus: Complex of F2-ITGAV-ITGB3 → Complex of ITGAV-ITGB3 (directlyIncreases, F2/ITGAV/ITGB3 Activity)
    Evidence: Our results show that VEGF can induce activation of the key integrins involved in angiogenesis, thereby establishing a mechanism by which the VEGF/VEGFR system can regulate cellular adhesive and migratory responses. Prothrombin, recently identified as an activation- dependent ligand of aVb3 (Byzova and Plow, 1998), supported limited adhesion of nonstimulated HUVECs; however, when these cells were stimulated with as little as 10 ng/ml VEGF165, adhesion to prothrombin increased by more than 10-fol...
  • OpenBEL Selventa BEL large corpus: Complex of ITGA2B-ITGB3 → F2 (increases, F2 Activity, ITGA2B/ITGB3 Activity)
    Evidence: 37 An initial conformational switch mechanism is consistent with the rapid and selective binding of a monovalent, ligand-mimetic antibody Fab fragment to IIb3 after platelet activation.38 Moreover, fluorescence resonance energy transfer studies using monoclonal antibodies bound to extracellular domains of IIb and 3 show that platelet activation is associated with a change in the relative orientation of the subunits.39 Electron micrographs of purified IIb3 have shown that fibrinogen binding to th...