Gene interactions and pathways from curated databases and text-mining

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ITGB3 — TLN1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Calderwood et al., Biochem Soc Trans 2004 : Formation of this talin-integrin complex plays a critical role in integrin activation, since mutations, in either talin or integrin beta tails, which disrupt complex formation, inhibit integrin activation
Ithychanda et al., J Biol Chem 2009 : Binding of the actin linking protein, talin, to integrin beta cytoplasmic tails ( CTs ) induces high affinity ligand binding ( integrin activation ), whereas binding of another actin linking protein, filamin, to the integrin beta CTs negatively regulates this process by blocking the talin-integrin interaction
Goult et al., J Mol Biol 2009 : We also demonstrate that F0 is required for the ability of kindlin-1 to support talin induced alphaIIbbeta3 integrin activation and for the localization of kindlin-1 to focal adhesions
Nishimura et al., Blood 2012 (Thrombosis) : Actin linker talin dependent activation of alphaIIb-beta3 integrin or Rac1 in platelets was required for late-phase thrombus stability