◀ Back to TLN1
ITGB3 — TLN1
Pathways - manually collected, often from reviews:
-
KEGG Focal adhesion:
TLN1/TLN2
→
Complex of 21 proteins
(protein-protein, binding/association)
-
NCI Pathway Database Nectin adhesion pathway:
nectin-1(dimer)/I-afadin/I-afadin/nectin-3(dimer)/I-afadin/I-afadin complex (PVRL1-MLLT4-PVRL3)
→
alphav/beta3 Integrin/Talin complex (TLN1-ITGAV-ITGB3)
(modification, activates)
Sakamoto et al., J Biol Chem 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database Nectin adhesion pathway:
alphav/beta3 Integrin complex (ITGAV-ITGB3)
→
Talin (TLN1)
(modification, collaborate)
Tadokoro et al., Science 2003*
Evidence: assay, physical interaction
-
NCI Pathway Database Nectin adhesion pathway:
alphav/beta3 Integrin complex (ITGAV-ITGB3)
→
alphav/beta3 Integrin/Talin complex (TLN1-ITGAV-ITGB3)
(modification, collaborate)
Tadokoro et al., Science 2003*
Evidence: assay, physical interaction
-
NCI Pathway Database Nectin adhesion pathway:
Talin (TLN1)
→
alphav/beta3 Integrin/Talin complex (TLN1-ITGAV-ITGB3)
(modification, collaborate)
Tadokoro et al., Science 2003*
Evidence: assay, physical interaction
-
NCI Pathway Database Integrins in angiogenesis:
None
→
alphav/beta3 Integrin/Talin complex (TLN1-ITGAV-ITGB3)
(modification, activates)
-
NCI Pathway Database Integrins in angiogenesis:
alphav/beta3 Integrin complex (ITGAV-ITGB3)
→
Talin (TLN1)
(modification, collaborate)
-
NCI Pathway Database Integrins in angiogenesis:
alphav/beta3 Integrin complex (ITGAV-ITGB3)
→
alphav/beta3 Integrin/Talin complex (TLN1-ITGAV-ITGB3)
(modification, collaborate)
-
NCI Pathway Database Integrins in angiogenesis:
Talin (TLN1)
→
alphav/beta3 Integrin/Talin complex (TLN1-ITGAV-ITGB3)
(modification, collaborate)
-
Reactome Reaction:
ITGB3
→
TLN1
(reaction)
Giancotti et al., Science 1999, Schaller et al., Biochim Biophys Acta 2001, Obergfell et al., J Cell Biol 2002, Giuliano et al., Biochem J 2003, Parsons et al., J Cell Sci 2003, Calderwood et al., J Cell Sci 2004, Li et al., Biochem Soc Trans 2004, Shattil et al., Trends Cell Biol 2005, Defilippi et al., Trends Cell Biol 2006, Mitra et al., Curr Opin Cell Biol 2006, Wegener et al., Cell 2007, Critchley et al., J Cell Sci 2008, Kurosaki et al., J Exp Med 1994, Gao et al., EMBO J 1997
-
Reactome Reaction:
ITGB3
→
TLN1
(indirect_complex)
Giancotti et al., Science 1999, Obergfell et al., J Cell Biol 2002, Calderwood et al., J Cell Sci 2004, Li et al., Biochem Soc Trans 2004, Shattil et al., Trends Cell Biol 2005, Arias-Salgado et al., J Cell Biol 2005, Wegener et al., Cell 2007, Critchley et al., J Cell Sci 2008
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
TLN1
—
ITGB3
García-Alvarez et al., Mol Cell 2003*
-
IRef Bind Interaction:
TLN1
—
ITGB3
García-Alvarez et al., Mol Cell 2003*
-
IRef Bind Interaction:
TLN1
—
ITGB3
García-Alvarez et al., Mol Cell 2003*
-
IRef Bind_translation Interaction:
TLN1
—
ITGB3
(x-ray crystallography)
García-Alvarez et al., Mol Cell 2003*
-
IRef Bind_translation Interaction:
TLN1
—
ITGB3
(x-ray crystallography)
García-Alvarez et al., Mol Cell 2003*
-
IRef Bind_translation Interaction:
TLN1
—
ITGB3
(x-ray crystallography)
García-Alvarez et al., Mol Cell 2003*
-
IRef Biogrid Interaction:
TLN1
—
ITGB3
(direct interaction, pull down)
Patil et al., J Biol Chem 1999*
-
IRef Biogrid Interaction:
TLN1
—
ITGB3
(direct interaction, pull down)
Calderwood et al., J Biol Chem 2002*
-
MIPS CORUM ITGA2b-ITGB3-TLN1 complex:
ITGA2b-ITGB3-TLN1 complex complex (ITGA2B-ITGB3-TLN1)
Knezevic et al., J Biol Chem 1996*
-
IRef Corum Interaction:
Complex of ITGB3-ITGA2B-TLN1
(association, affinity chromatography technology)
Knezevic et al., J Biol Chem 1996*
-
IRef Hprd Interaction:
Complex of ITGB3-TLN1-TLN1-ITGB3-ITGA2B-ITGA2B-ITGA2B-ITGB3-TLN1
(in vivo)
Knezevic et al., J Biol Chem 1996*
-
IRef Hprd Interaction:
ITGB3
—
TLN1
(in vivo)
Patil et al., J Biol Chem 1999*, Calderwood et al., J Biol Chem 2002*, Calderwood et al., Proc Natl Acad Sci U S A 2003
-
IRef Hprd Interaction:
ITGB3
—
TLN1
(in vitro)
Patil et al., J Biol Chem 1999*, Calderwood et al., J Biol Chem 2002*, Calderwood et al., Proc Natl Acad Sci U S A 2003
-
IRef Intact Interaction:
TLN1
—
ITGB3
(direct interaction, enzyme linked immunosorbent assay)
Xing et al., FEBS Lett 2006*
-
IRef Intact Interaction:
TLN1
—
ITGB3
(direct interaction, saturation binding)
Xing et al., FEBS Lett 2006*
-
IRef Intact Interaction:
TLN1
—
ITGB3
(direct interaction, affinity technology)
Xing et al., FEBS Lett 2006*
-
IRef Ophid Interaction:
TLN1
—
ITGB3
(aggregation, confirmational text mining)
Patil et al., J Biol Chem 1999*
-
IRef Ophid Interaction:
TLN1
—
ITGB3
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Calderwood et al., Biochem Soc Trans 2004
:
Formation of this
talin-integrin complex
plays a critical role in integrin activation, since mutations, in either talin or
integrin beta tails, which disrupt complex formation, inhibit integrin activation
Ithychanda et al., J Biol Chem 2009
:
Binding of the actin linking protein, talin, to
integrin beta cytoplasmic tails ( CTs )
induces high affinity ligand binding ( integrin activation ), whereas binding of another actin linking protein, filamin, to the integrin beta CTs negatively regulates this process by blocking the
talin-integrin interaction
Goult et al., J Mol Biol 2009
:
We also demonstrate that F0 is required for the ability of kindlin-1 to support
talin induced
alphaIIbbeta3 integrin activation and for the localization of kindlin-1 to focal adhesions
Nishimura et al., Blood 2012
(Thrombosis) :
Actin linker
talin dependent activation of
alphaIIb-beta3 integrin or Rac1 in platelets was required for late-phase thrombus stability