Gene interactions and pathways from curated databases and text-mining

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ABL1 — JUN

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Barilá et al., EMBO J 2000 : Surprisingly, elevated levels of c-Jun activated nuclear Abl , resulting in activation of the JNK serine/threonine kinase
Perrotti et al., Mol Cell Biol 2000 : FUS proteolysis is induced by c-Jun , is suppressed by BCR-ABL or Jun kinase 1, and does not depend on c-Jun transactivation potential, ubiquitination, or its interaction with Jun kinase 1
Mancini et al., Traffic 2009 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : In particular, constitutive tyrosine kinase ( TK ) activity of p210 BCR-ABL blocks c-Jun N-terminal kinase (JNK) phosphorylation leading to 14-3-3 sigma phosphorylation at a critical residue ( Ser ( 186 ) ) for c-ABL binding in response to DNA damage
Kobayashi et al., Leukemia 2009 (Leukemia, Myeloid, Chronic-Phase) : BCR-ABL directly inhibited c-Jun expression, as c-Jun downregulation in primary CML neutrophils and in the CML blast cell lines, KCL22 and K562, was reversed by the tyrosine kinase inhibitor imatinib