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Neagoe et al., J Biol Chem 2005
:
In summary, our data demonstrate that the activation of VEGFR-1 and
VEGFR-2 heterodimer ( VEGFR-1/R-2 ) is
essential for
PGI ( 2 ) synthesis mediated by VEGF-A ( 165 ) and VEGF-A ( 121 ), which can not be reproduced by the parallel activation of VEGFR-1 and VEGFR-2 homodimers with corresponding agonists
Watari et al., Int J Cancer 2012
:
AMF-26 was found to
inhibit the phosphorylation of VEGF receptor 1 (VEGFR1),
VEGFR2 and the downstream signaling molecules Akt, extracellular signal regulated kinase ( ERK ) 1/2 stimulated by VEGF in HUVECs