Gene interactions and pathways from curated databases and text-mining

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INS — KLK3

Text-mined interactions from Literome

Liu et al., Mol Cell Biol 2002 : Insulin stimulated phosphorylation of tyrosine 618 in APS is necessary for its association with c-Cbl and the subsequent tyrosine phosphorylation of Cbl by the insulin receptor in both 3T3-L1 adipocytes and CHO-IR cells
Mori et al., Mol Cell Endocrinol 2005 : In spite of these differences, both FL-Grb10 and the BPS-SH2 fragment inhibited insulin stimulated phosphorylation of IRS1, IRS2, Akt/PKB, Shc, ERK1/2, APS , and c-Cbl to a similar extent
Katsanakis et al., J Biol Chem 2005 : The insulin stimulated serine phosphorylation of APS was inhibited by a PI3-kinase inhibitor, LY290004, a specific protein kinase B (PKB) inhibitor, deguelin, and knockdown of Akt ... Serine 588 of APS is contained in a protein kinase B consensus sequence for phosphorylation conserved in APS across multiple species but not found in other members of this family, including SH2-B and Lnk. Mutation of serine 588 to alanine abolished the insulin stimulated serine phosphorylation of APS and prevented the localization of APS to membrane ruffles
Li et al., Endocrinology 2006 (Body Weight...) : SH2-B and APS , two members of a pleckstrin homology and SH2 domain containing adaptor family, promote both insulin and leptin signaling in a similar fashion in cultured cells
Ji et al., Acta Pharmacol Sin 2007 (Pulmonary Edema) : In vivo experiments showed a significant glucose level decrease and insulin absorption increase ( P < 0.05 ) in the presence of APS , compared to the insulin solution alone. From the results, we found that the pulmonary edema index values of all the INSAPS groups were significant lower ( P < 0.05 ) than that of the insulin solution group, and there were no significant differences ( P > 0.05 ) between INS/DPPC/Tyl, INS/ DPPC/PG, and the control group
Onnockx et al., J Cell Physiol 2008 : We also observed that SHIP2 negatively regulates APS insulin induced tyrosine phosphorylation and consequently inhibits APS association with c-Cbl
Mao et al., Phytomedicine 2009 (Body Weight...) : APS enhanced adaptive capacity of the ER and promoted insulin signaling by the inhibition of the expression and activity of PTP1B
Li et al., Zhong Yao Cai 2011 (Diabetes Mellitus, Experimental) : To observe the effects of Astragalus polysaccharides (APS) on the BG, insulin and C-peptide in serum, ultrastructure and Fas expression of pancreatic beta-cells in diabetes mellitus ( DM ) rats
Sugai et al., J Clin Psychopharmacol 2012 (Insulin Resistance) : These results suggest that APs affect the glucose-insulin response, which may lead to subclinical insulin resistance before the onset of overt glucose intolerance