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INS — KLK3
Text-mined interactions from Literome
Liu et al., Mol Cell Biol 2002
:
Insulin stimulated phosphorylation of tyrosine 618 in
APS is necessary for its association with c-Cbl and the subsequent tyrosine phosphorylation of Cbl by the insulin receptor in both 3T3-L1 adipocytes and CHO-IR cells
Mori et al., Mol Cell Endocrinol 2005
:
In spite of these differences, both FL-Grb10 and the BPS-SH2 fragment inhibited
insulin stimulated phosphorylation of IRS1, IRS2, Akt/PKB, Shc, ERK1/2,
APS , and c-Cbl to a similar extent
Katsanakis et al., J Biol Chem 2005
:
The
insulin stimulated serine phosphorylation of
APS was inhibited by a PI3-kinase inhibitor, LY290004, a specific protein kinase B (PKB) inhibitor, deguelin, and knockdown of Akt ... Serine 588 of APS is contained in a protein kinase B consensus sequence for phosphorylation conserved in APS across multiple species but not found in other members of this family, including SH2-B and Lnk. Mutation of serine 588 to alanine abolished the
insulin stimulated serine phosphorylation of
APS and prevented the localization of APS to membrane ruffles
Li et al., Endocrinology 2006
(Body Weight...) :
SH2-B and
APS , two members of a pleckstrin homology and SH2 domain containing adaptor family,
promote both
insulin and leptin signaling in a similar fashion in cultured cells
Ji et al., Acta Pharmacol Sin 2007
(Pulmonary Edema) :
In vivo experiments showed a significant glucose level decrease and
insulin absorption increase ( P < 0.05 ) in the
presence of
APS , compared to the insulin solution alone. From the results, we found that the pulmonary edema index values of all the INSAPS groups were significant lower ( P < 0.05 ) than that of the insulin solution group, and there were no significant differences ( P > 0.05 ) between INS/DPPC/Tyl, INS/ DPPC/PG, and the control group
Onnockx et al., J Cell Physiol 2008
:
We also observed that SHIP2 negatively regulates
APS insulin induced tyrosine phosphorylation and consequently inhibits APS association with c-Cbl
Mao et al., Phytomedicine 2009
(Body Weight...) :
APS enhanced adaptive capacity of the ER and
promoted insulin signaling by the inhibition of the expression and activity of PTP1B
Li et al., Zhong Yao Cai 2011
(Diabetes Mellitus, Experimental) :
To observe the
effects of
Astragalus polysaccharides (APS) on the BG,
insulin and C-peptide in serum, ultrastructure and Fas expression of pancreatic beta-cells in diabetes mellitus ( DM ) rats
Sugai et al., J Clin Psychopharmacol 2012
(Insulin Resistance) :
These results suggest that
APs affect the
glucose-insulin response, which may lead to subclinical insulin resistance before the onset of overt glucose intolerance