◀ Back to KRT8
KRT18 — KRT8
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of CFLAR-KRT18-KRT8-RAF1
→
FAS
(increases)
Gilbert et al., Mol Cell Biol 2004*
Evidence: c-Flip, along with Raf-1, is part of a K8/K18-immunoisolated complex from wild-type hepatocytes, and Fas stimulation leads to further c-Flip and Raf-1 recruitment in the complex.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Biogrid Interaction:
KRT18
—
KRT8
(direct interaction, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Biogrid Interaction:
KRT18
—
KRT8
(direct interaction, two hybrid)
Schnabel et al., Biochim Biophys Acta 1998*
-
IRef Dip Interaction:
KRT18
—
KRT8
(physical association, two hybrid)
Meng et al., J Biol Chem 1996*
-
Gene Ontology Complexes intermediate filament:
intermediate filament complex (KRT39-KRT38-KRTAP4-2-KRT31-NME1-NME2-KRT32-KRT35-KRT34-KRT37-KRT36-KRT222-KRTAP4-6-KRTAP3-1-MICAL1-KRTAP1-1-KRT28-KRTAP1-3-KRTAP1-4-KRTAP1-5-KRT23-KRT20-KRT26-KRT27-KRT24-KRT25-LMNTD1-KRTAP21-3-KRTAP27-1-KRTAP20-2-KRTAP20-3-KRTAP20-1-KRTAP20-4-KRTAP10-8-KRTAP6-2-KRTAP10-5-KRTAP10-4-KRTAP10-3-KRTAP10-2-KRTAP10-1-VIM-KRTAP23-1-KRTAP25-1-SYNM-DES-SYNC-PRPH-FLG-KRTAP4-9-KRTAP9-9-KRTAP7-1-KRTAP9-1-KRTAP9-2-KRTAP9-3-KRTAP9-4-KRTAP4-4-KRTAP9-6-KRTAP9-7-JUP-KRT40-KRTAP10-12-DSP-KRTAP10-10-KRTAP12-1-GJA1-KRTAP12-3-KRTAP12-2-KRTAP12-4-KRTAP24-1-KRT17-KRT16-KRT15-KRT14-KRT12-KRT10-INA-KRT19-KRT18-KRT75-KRT74-KRT77-KRT76-KRT71-KRT73-KRT72-KRT79-KRT78-KRT3-KRT2-KRT1-KRT7-KRT4-KRT9-KRT8-NES-KRTAP5-10-KRT80-KRT81-KRT82-KRT83-KRT84-KRT85-KRT86-KRTAP19-2-KRTAP19-3-KRTAP19-1-KRT6B-KRT6C-KRTAP19-4-KRT6A-KRTAP19-6-KRTAP19-8-KRTAP19-7-KRTAP5-4-LMNB2-KRTAP5-6-KRTAP5-7-KRTAP5-1-KRTAP5-2-KRTAP5-3-KRTAP2-3-KRTAP2-1-KRTAP19-5-KRTAP5-9-KRTAP15-1-LMNB1-KRTAP4-16P-KRTAP2-4-KRTAP16-1-KRTAP21-2-KRTAP21-1-KRTAP11-1-KRTAP22-1-KRTAP22-2-KRTAP5-5-EIF6-KRTAP4-5-KRTAP8-1-KRTAP29-1-NCKIPSD-KRT87P-NEFL-KRT33A-KRTAP6-3-NEFH-KRTAP6-1-CLIP1-KRTAP17-1-GFAP-KRTAP4-8-KRTAP3-2-BFSP2-MNS1-BFSP1-KRTAP13-4-KRTAP13-1-KRTAP13-2-KRTAP13-3-KRTAP4-11-LMNA-KRTAP4-12-KRTAP26-1-KRTAP3-3-NEFM-KRT33B-SLC1A4-KRTAP4-3)
de Bernard et al., EMBO J 2000, Hofmann et al., J Cell Sci 2000, Suzuki et al., J Biol Chem 2002, Collin et al., Differentiation 1992, Collin et al., Exp Cell Res 1992, Bilbe et al., EMBO J 1992, Yang et al., Circ Res 2006, Langbein et al., J Biol Chem 2010, Glass et al., J Cell Biol 1985, Leube et al., J Cell Biol 1988, Zhou et al., J Biol Chem 1988, McKinley-Grant et al., Proc Natl Acad Sci U S A 1989, Moll et al., Differentiation 1993, Ku et al., J Biol Chem 1997, Irvine et al., Nat Genet 1997, Winter et al., J Biol Chem 1997, Hess et al., Exp Eye Res 1998, Muñoz-Mármol et al., Proc Natl Acad Sci U S A 1998, Yaworsky et al., Dev Biol 1999
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IRef Hprd Interaction:
Complex of KRT18-KRT8-KRT18-TRO-TRO-KRT8-KRT18-KRT8-TRO
(in vivo)
Suzuki et al., Proc Natl Acad Sci U S A 1998
-
IRef Hprd Interaction:
Complex of 1567 proteins
(in vivo)
Catimel et al., J Proteome Res 2005
-
IRef Hprd Interaction:
Complex of 57 proteins
(in vivo)
Catimel et al., J Proteome Res 2005
-
IRef Hprd Interaction:
KRT18
—
KRT8
(in vivo)
Schnabel et al., Biochim Biophys Acta 1998*
-
IRef Intact Interaction:
Complex of KRT18-KRT8-DNAJB6
(physical association, cosedimentation)
Izawa et al., J Biol Chem 2000
-
IRef Intact Interaction:
Complex of 54 proteins
(association, tandem affinity purification)
Pozuelo-Rubio et al., FEBS J 2010
-
IRef Intact Interaction:
Complex of 228 proteins
(association, pull down)
Blagoev et al., Nat Biotechnol 2003
-
IRef Intact Interaction:
Complex of 14 proteins
(association, anti bait coimmunoprecipitation)
Colas et al., Hum Mol Genet 2012
-
IRef Intact Interaction:
Complex of 156 proteins
(association, anti tag coimmunoprecipitation)
Lau et al., Cell 2012
-
IRef Intact Interaction:
KRT18
—
KRT8
(colocalization, confocal microscopy)
Wang et al., Molecular systems biology 2011
-
IRef Intact Interaction:
KRT18
—
KRT8
(physical association, cosedimentation)
Inada et al., J Cell Biol 2001*
-
IRef Intact Interaction:
KRT18
—
KRT8
(physical association, cosedimentation)
Izawa et al., J Biol Chem 2000
-
IRef Intact Interaction:
KRT18
—
KRT8
(physical association, two hybrid)
Izawa et al., J Biol Chem 2000
-
IRef Intact Interaction:
KRT18
—
KRT8
(physical association, biophysical)
Waseem et al., Biochemistry 2004*
-
IRef Intact Interaction:
KRT18
—
KRT8
(physical association, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Intact Interaction:
Complex of KRT18-TRADD-TRADD-KRT8-KRT8-KRT18
(colocalization, fluorescence microscopy)
Inada et al., J Cell Biol 2001*
-
IRef Intact Interaction:
Complex of 38 proteins
(association, pull down)
Blagoev et al., Nat Biotechnol 2003
-
IRef Ophid Interaction:
KRT18
—
KRT8
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Ku et al., Hepatology 2003
(Liver Diseases) :
Both Fas- and TNF induced apoptosis in liver tissues are associated with caspase mediated
K18 degradation and
increased keratin phosphorylation on several but not all sites
Effenberger et al., Breast Cancer Res Treat 2011
(Breast Neoplasms...) :
Among the analyzed CK, AE
detected CK5, CK7,
CK8 , and CK19, whereas A45 recognized CK7 and
CK18