Gene interactions and pathways from curated databases and text-mining

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KRT18 — KRT8

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of CFLAR-KRT18-KRT8-RAF1 → FAS (increases) Gilbert et al., Mol Cell Biol 2004*
    Evidence: c-Flip, along with Raf-1, is part of a K8/K18-immunoisolated complex from wild-type hepatocytes, and Fas stimulation leads to further c-Flip and Raf-1 recruitment in the complex.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ku et al., Hepatology 2003 (Liver Diseases) : Both Fas- and TNF induced apoptosis in liver tissues are associated with caspase mediated K18 degradation and increased keratin phosphorylation on several but not all sites
Effenberger et al., Breast Cancer Res Treat 2011 (Breast Neoplasms...) : Among the analyzed CK, AE detected CK5, CK7, CK8 , and CK19, whereas A45 recognized CK7 and CK18