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CSF2 — LEO1

Text-mined interactions from Literome

Simon et al., J Immunol 2000 (Eosinophilia) : In a model of eosinophil degranulation, we show that eosinophils release ECP upon short-term GM-CSF priming and stimulation with either platelet activating factor (PAF) or the anaphylatoxin C5a, but not eotaxin
Thomet et al., Biochem Pharmacol 2001 : A large production of leukotrienes ( LTs ) can be induced in human eosinophils or neutrophils by priming with granulocyte-macrophage colony stimulating factor and subsequent stimulation with platelet activating factor (PAF) or the anaphylatoxin C5a
Thomet et al., Clin Exp Allergy 2001 (Inflammation) : Priming of eosinophils with granulocyte-macrophage colony stimulating factor ( GM-CSF ) and subsequent stimulation with platelet activating factor (PAF) or the anaphylatoxin C5a is associated with a rapid production of leukotrienes ( LTs ) and release of eosinophil cationic protein (ECP)
Warringa et al., Blood 1991 : We have investigated the modulatory role of GM-CSF and IL-3 on the platelet activating factor (PAF)- , neutrophil activating factor ( NAF/IL-8 ) -, leukotriene B4 (LTB4)-, N-formyl-methionyl-leucyl-phenylalanine ( FMLP ) -, and human complement factor C5a induced chemotaxis of eosinophils from normal individuals
DeNichilo et al., J Biol Chem 1991 : GM-CSF stimulated the synthesis but not the release of PAF from neutrophils
Sharif et al., Molecular vision 2009 : PAF induced production of IL-6, IL-8, and GM-CSF from HCECs was also blocked by these PAF antagonists ( IC ( 50 ) =4.6- 8.6 microM )
Sharif et al., J Ocul Pharmacol Ther 2010 : PAF increased the production of PGE ( 2 ) ( with maximum effect at 30 and 100 nM ) and GM-CSF ( maximum effect at 1 microM ) in CEPI-17-CL4 cells
Wirthmueller et al., Biochem Biophys Res Commun 1990 : GM-CSF stimulates uridine incorporation into RNA and inhibitors for RNA and protein synthesis decrease PAF synthesis in our model
Yamazaki et al., Proc Natl Acad Sci U S A 1989 : The PAF synthesis in human neutrophils stimulated by PAF is greatly potentiated by the human granulocyte-macrophage colony stimulating factor
Stewart et al., Immunology 1994 : Thus, we have compared the priming effects of rhG-CSF and rhGM-CSF on superoxide anion ( O2- ) generation and platelet activating factor (PAF) synthesis by neutrophils
Tao et al., J Leukoc Biol 1993 : These results suggest that ( 1 ) PAF and r-BoIL-1 beta activate bovine neutrophils by different mechanisms, ( 2 ) r-BoGM-CSF primes superoxide production and degranulation induced by PAF, ( 3 ) r-BoGM-CSF primes superoxide production but not degranulation induced by r-BoIL-1 beta, and ( 4 ) the priming effect of r-BoGM-CSF is not mediated by PAF
Dupuis et al., Biochim Biophys Acta 1996 : M-CSF ( up to 1000 U/ml ) and GM-CSF ( up to 10 ng/ml ) did not induce PAF production by human blood monocytes
Lacasse et al., Inflammation 1997 (Inflammation) : GM-CSF production by EC was also stimulated by the combined effects of PAF and TNF alpha, but PAF alone did not affect GM-CSF production
Dupuis et al., Res Immunol 1997 : By contrast, M-CSF ( 1000 U/ml ), GM-CSF ( 100 ng/ml ), IL1, IL3, IL6 and stem cell factor ( 10 ng/ml ) did not stimulate PAF production
Sharif et al., Invest Ophthalmol Vis Sci 1998 : Histamine ( 100 microM ) and interleukin-1alpha ( IL-1alpha, 10 ng/ml ) significantly stimulated IL-6 and granulocyte macrophage colony stimulating factor release, and histamine, BK, and PAF stimulated the mRNA for MMP-1 in these cells