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LIF — MAPK8

Text-mined interactions from Literome

Kim et al., J Biol Chem 1999 : Notably, leukemia inhibitory factor , but not interferon-gamma, also promoted ErbB-2 shift and mitogen activated protein kinase activation
Bartoe et al., J Neurochem 2000 : Furthermore, LIF stimulated MAPK activation negatively regulates this VIP reporter gene induction
Ng et al., J Biol Chem 2001 (Hypertrophy...) : In contrast, LIF promoted strong activation of ERKs, marginal activation of p38 ( MAPK ), and no c-Jun N-terminal kinase activation
Thabard et al., Cytokine 2001 (MAP Kinase Signaling System...) : In OPM-2 cells, IL-6, OSM and LIF induce both signal transducers and activators of transcription ( STAT ), mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3-kinase (PI 3-K) activation
Nakao et al., Br J Pharmacol 2002 : 3 : Both PD98059 ( MAPK/ERK kinase inhibitor ) and SB203580 ( p38 MAPK inhibitor ) attenuated FCS induced LIF protein production and gene expression ... 5 : These findings demonstrate that both ERK and p38 MAPK are involved in FCS induced LIF secretion, whereas only p38 MAPK is important for IL-6 secretion, and that FCS induced activation of JNK has no effect on the production of LIF and IL-6
Annerén et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Src family kinase inhibition does not interfere with LIF induced JAK/STAT3 ( Janus associated tyrosine kinases/signal transducer and activator of transcription 3 ) or p42/p44 MAPK ( mitogen activated protein kinase ) phosphorylation
Yagi et al., J Gastroenterol 2007 (Colitis) : Inhibitors for ERK ( PD98059 and U0216 ) and p38 MAPK ( SB203580 ) significantly reduced the IL-17F induced IL-6, IL-8, LIF , MMP-1, and MMP-3 secretion
Carino et al., Int J Cancer 2008 (Adenocarcinoma...) : Leptin induction of cytokines/receptors generally involved JAK2 and MAPK activation, but PI-3K phosphorylation was required for leptin increase of LIF , IL-1/IL-1R tI
Nishishita et al., PloS one 2012 : Then, single cells from colonies were seeded on PronectinFr coated 96-well plates and cultured under naïve culture conditions ( N2B27 based medium supplemented with LIF , forskolin, a MAPK inhibitor , and a GSK inhibitor in 5 % O2 ) for cloning purpose
Fahmi et al., Cell Signal 2013 (Hypertrophy...) : Both LIF and IL-6 [ in the absence of soluble IL-6 receptor ( sIL-6Ra ) ] activated Erk1/2, JNK1/2, p38-MAPK and PI3K signalling peaking at 20min and induced cytoprotection against simulated ischemia-reperfusion injury which was blocked by the MEK1/2 inhibitor PD98059 but not the p38-MAPK inhibitor SB203580
Agca et al., Cell death & disease 2013 (Disease Models, Animal...) : Inhibition of p38 MAPK activity reduced the Lif expression also in the model of light induced retinal degeneration and resulted in increased cell death in the light exposed retina
Schiemann et al., J Biol Chem 1994 : Interestingly, down-regulation of protein kinase C ( PKC ) by chronic treatment of 3T3-L1 cells with phorbol ester was found to attenuate, but not block, the LIF mediated stimulation of MAPKK, MAPK , and S6K activities in 3T3-L1 cells
Schiemann et al., Oncogene 1998 : Raf-1 independent stimulation of mitogen activated protein kinase by leukemia inhibitory factor in 3T3-L1 cells