Gene interactions and pathways from curated databases and text-mining

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LPO — TNF

Text-mined interactions from Literome

Cheng et al., Shock 2005 : Thus, Pb increased LPS induced liver damage through PKC and p42/44 MAPK modulation of TNF-alpha and oxidative stress, but modulation of TNF-alpha did not affect NO or LPO in rats
Dudnik et al., Izv Akad Nauk Ser Biol 2007 (Cholestasis, Extrahepatic) : The synergistic interaction can sharply increase the proapoptotic capacity of each of these factors since TNFalpha activates SMase and LPO , SMase activity depends on the LPO rate, while ceramide, an SMase produced secondary messenger of apoptosis, can induce oxidative stress