Jozefowski et al., Immunology 2005
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Consistent with the effects of leukotriene antagonists, exogenous LTB ( 4 ) enhanced LPS stimulated IL-10 release by approximately 39 % and inhibited IL-12 p40 release by approximately 22 %
Rola-Pleszczynski et al., Union Med Can 1989
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In particular, LTB4 can induce suppressor cells, activate the synthesis and production of lymphokines such as interleukin 2 or interferon-gamma, stimulate the production of interleukin 1 by monocytes or macrophages, and activate cytotoxic cells against virus infected or tumor target cells
Arcoleo et al., Int J Immunopharmacol 1995
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However, LTB4 augmented ConA spleen cell production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) from Th1 cells and interleukin-4 (IL-4) and interleukin-10 (IL-10) from Th2 cells more than the controls treated with ConA alone