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JAK2 — LYN

Pathways - manually collected, often from reviews:

• NCI Pathway Database CXCR4-mediated signaling events: SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, activates)
  Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2) → EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN) (modification, activates)
  Penta et al., J Biol Chem 1995
  Evidence: assay, other species
• NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2) → EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN) (modification, activates)
  Ren et al., J Biol Chem 1994*
  Evidence: assay
• NCI Pathway Database EPO signaling pathway: EPO/EPOR (dimer)/JAK2 complex (EPO-EPOR-JAK2) → EPO/EPOR (dimer)/LYN complex (EPO-EPOR-LYN) (modification, activates)
  Penta et al., J Biol Chem 1995
  Evidence: assay, other species
• Reactome Reaction: JAK2 → LYN (reaction) Argetsinger et al., Mol Cell Biol 2004, Argetsinger et al., Mol Endocrinol 2010, Weiler et al., Blood 1996, Feng et al., Mol Cell Biol 1997
• Reactome Reaction: JAK2 → LYN (indirect_complex) Brizzi et al., J Biol Chem 1999, Ning et al., Oncogene 2001, Argetsinger et al., Mol Cell Biol 2004, Argetsinger et al., Mol Endocrinol 2010, Weiler et al., Blood 1996, Feng et al., Mol Cell Biol 1997, Deberry et al., Biochem J 1997

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: LYN — JAK2 (direct interaction, pull down) Chin et al., Blood 1998*
• IRef Hprd Interaction: LYN — JAK2 (in vitro) Chin et al., Blood 1998*
• IRef Ophid Interaction: LYN — JAK2 (aggregation, confirmational text mining) Chin et al., Blood 1998*
• IRef Ophid Interaction: LYN — JAK2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Wang et al., Oncogene 2007 : We found that activated BCR results in tyrosine phosphorylation of JAK-STAT , which required Lyn
Shuh et al., J Virol 2011 (Cell Transformation, Viral) : Association of SRC related kinase Lyn with the interleukin-2 receptor and its role in maintaining constitutive phosphorylation of JAK/STAT in human T-cell leukemia virus type 1-transformed T cells
Simon et al., Eur J Immunol 1997 : In addition, since Lyn remained unaffected by tyrphostin B42, it is unlikely that Jak2 is required for Lyn activation in this model
Chin et al., Blood 1998 : These results suggest that Lyn may play a role in activation of the Jak2/Stat5 and other signaling pathways by the EpoR