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Liu et al., Am J Physiol Lung Cell Mol Physiol 2003
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Blocking ERK1/2 activation by MEK1/2 inhibitors ( PD-98059 or U-0126 ) diminishes HB-EGF induced Fra-1 accumulation and subsequent downregulation of elastin mRNA
Hoffmann et al., J Biol Chem 2005
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Additional experiments reveal that, in conjunction with p65 NF-kappaB, the MEK1-ERK dependent synthesis of c-Fos and Fra-1 serves to adjust the overall expression level of IL-8 in response to two of its physiological inducers, IL-1 and epidermal growth factor