Gene interactions and pathways from curated databases and text-mining

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MAP2K1 — MAP2K4

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

  • STRING interaction: MAP2K1 — MAP2K4 (interaction, mapped from kegg_pathways mint intact)
  • STRING interaction: MAP2K4 — MAP2K1 (interaction, mapped from kegg_pathways mint intact)

Text-mined interactions from Literome

Zhang et al., Arterioscler Thromb Vasc Biol 2005 (Vasculitis) : In contrast, mitogen activated protein kinase kinase-1 ( MEK1 ) inhibition ( dominant negative MEK1 adenovirus or inhibitor U0126 ) suppressed Ang II-induced NF-kappaB promoter activity, NF-kappaB DNA binding activity, p65 phosphorylation, and led to 70 % reduction in IL-6 transcription/production
Shapiro et al., J Biol Chem 1998 : Coexpression of MKK1 or MKK2 with MKP-1 resulted in 7-10-fold activation of mitogen activated protein kinase kinase ( MKK ), which required the presence of regulatory serine phosphorylation sites