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MAP2K5 — MAPK7

Pathways - manually collected, often from reviews:

• BioCarta mapkinase signaling pathway: MEK5 (MAP2K5) → ERK5 (MAPK7) (modification, activates)
• BioCarta role of erk5 in neuronal survival pathway: MEK5 (MAP2K5) → ERK5 (MAPK7) (modification, activates)
• KEGG Gap junction: MAP2K5 → MAPK7 (protein-protein, activation)
• KEGG Neurotrophin signaling pathway: MAP2K5 → MAPK7 (protein-protein, activation)
• KEGG MAPK signaling pathway: MAP2K5 → MAPK7 (protein-protein, phosphorylation)
• NCI Pathway Database Trk receptor signaling mediated by the MAPK pathway: MEK5 (MAP2K5) → ERK5 (MAPK7) (modification, activates) Watson et al., Nat Neurosci 2001*, Shao et al., J Cell Biol 2002*, Valdez et al., J Neurosci 2005*
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database ErbB1 downstream signaling: MEK5 (MAP2K5) → ERK5 (MAPK7) (modification, activates) Sun et al., J Biol Chem 2001*, Sun et al., Mol Cell Biol 2003*, Kato et al., Nature 1998*
  Evidence: other species
• Reactome Reaction: MAPK7 → MAP2K5 (reaction)
• WikiPathways ESC Pluripotency Pathways: MAP2K1/MAP2K3/SEPP1/MAP2K5/MAP2K6/MAP2K2 → MAPK7/MAPK1/MAPK6/MAPK4/MAPK12 (activation)
  
• WikiPathways Focal Adhesion: SEPP1/MAP2K5/MAP2K6/MAP2K2/MAP2K3/MAP2K1 → MAPK4/MAPK7/MAPK12/MAPK1/MAPK6 (activation)
  
• WikiPathways MAPK Signaling Pathway: MAP2K5 → MAPK7 (activation)
• WikiPathways MicroRNAs in cardiomyocyte hypertrophy: MAP2K5 → MAPK7 (activation)
• WikiPathways Cardiac Hypertrophic Response: MAP2K5 → MAPK7 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: MAP2K5 — MAPK7 Mody et al., Biochem J 2003*
• IRef Bind_translation Interaction: MAP2K5 — MAPK7 (experimental interaction detection) Mody et al., Biochem J 2003*
• IRef Biogrid Interaction: MAPK7 — MAP2K5 (direct interaction, two hybrid) Zhou et al., J Biol Chem 1995*
• IRef Biogrid Interaction: MAPK7 — MAP2K5 (direct interaction, pull down) Zhou et al., J Biol Chem 1995*
• IRef Hprd Interaction: MAP2K5 — MAPK7 (two hybrid) Zhou et al., J Biol Chem 1995*
• IRef Hprd Interaction: MAP2K5 — MAPK7 (in vitro) Zhou et al., J Biol Chem 1995*
• IRef Intact Interaction: MAP2K5 — MAPK7 (physical association, two hybrid) Zhou et al., J Biol Chem 1995*
• IRef Intact Interaction: MAP2K5 — MAPK7 (physical association, pull down) Zhou et al., J Biol Chem 1995*
• IRef Ophid Interaction: MAP2K5 — MAPK7 (aggregation, confirmational text mining) Zhou et al., J Biol Chem 1995*
• IRef Ophid Interaction: MAP2K5 — MAPK7 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• STRING interaction: MAPK7 — MAP2K5 (interaction, mapped from reactome mint intact)
• STRING interaction: MAP2K5 — MAPK7 (interaction, mapped from reactome mint intact)

Text-mined interactions from Literome

Martel-Pelletier et al., Arthritis Rheum 1999 (Osteoarthritis) : Within minutes, IL-17 induced the phosphorylation of mitogen activated protein kinase kinase-1/2 ( MEK-1/2 ), -3/6 ( MKK-3/6 ), p44/42, p38, and inhibitor of nuclear factor kappaB ( I kappaB)-alpha, as well as the activation of mitogen activated protein kinase activated protein kinase-1 and -2 ( MAPKAPK-1 and -2 )
Tu et al., J Biomed Sci 2001 (Carcinoma, Hepatocellular) : On the other hand, PD98059, a specific inhibitor of mitogen activated protein kinase kinase , blocks TPA induced MAPK activation but has no effect on TPA induced tyrosine phosphorylation
Huang et al., Biochem Biophys Res Commun 2003 : MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a mitogen activated protein kinase kinase ( MAP2K ), which in turn activates a mitogen activated protein kinase ( MAPK )
Cameron et al., J Biol Chem 2004 : Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation ... Furthermore, MEK5beta inhibited epidermal growth factor induced BMK1 activation and MEK5alpha ( S311D/T315D ) -induced MEF2 transcriptional activity ... Both MEK5alpha and MEK5beta individually co-immunoprecipitated with BMK1, but the presence of MEK5beta prevented association of MEK5alpha with BMK1 suggesting a mechanistic basis for the dominant negative behavior of MEK5beta on BMK1 activation
Pi et al., Circ Res 2004 : Analysis of cell viability with MTT assay showed that activation of BMK1 by CA-MEK5 significantly improved cell viability from 48 % to 87 % and decreased apoptotic cells from 49 % to 10 %
Pi et al., Circ Res 2005 : BMK1 activation by constitutively active ( CA ) -MEK5 inhibited HIF1alpha activity by 46+/-4 %, suggesting BMK1 functions as a negative regulator of HIF1alpha activation
Huwiler et al., Br J Pharmacol 1994 : 2. Both nucleotides stimulate phosphorylation and activation of mitogen activated protein kinase and a biphasic phosphorylation of the up-stream mitogen activated protein kinase kinase
Daum et al., FEBS Lett 1998 : Pervanadate inhibits mitogen activated protein kinase kinase-1 in a p38MAPK dependent manner
Kato et al., Nature 1998 : In contrast to Erk1/2, EGF mediated activation of Bmk1 occurs independently of Ras and requires the MAP-kinase kinase Mek5