Gene interactions and pathways from curated databases and text-mining

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IL3 — MAP3K7

Text-mined interactions from Literome

Frobøse et al., Mol Endocrinol 2006 : Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex
Thiefes et al., EMBO Rep 2006 : YopP, but not the catalytically inactive mutant YopP ( C172A ), also suppresses basal and interleukin-1-inducible activation of endogenous TAK1 , TAB1 and TAB2
Inagaki et al., J Biol Chem 2008 : Tumor necrosis factor- and interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
Kim et al., PloS one 2009 (Colitis) : Finally, we showed that TAK1 is essential for interleukin 1- and bacterial components induced expression of cytoprotective factors such as interleukin 6 and cycloxygenase 2