Momcilovic et al., J Biol Chem 2006
:
Finally, expression of TAK1 and TAB1 in HeLa cells or treatment of cells with cytokines stimulated phosphorylation of Thr-172 of AMPK Scholz et al., J Biol Chem 2010
:
TAK1 dependent AMPK activation was mediated via hydrophobic residues of the AMPK kinase domain alphaG-helix as observed in vitro and in transfected cell culture
Lee et al., Bone 2010
(Bone Resorption) :
AMPK negatively regulates RANKL, possibly by acting through CaMKK and TAK1 Chen et al., Mol Cell Biochem 2013
:
TAK1 inhibitor significantly suppressed H2O2 induced AMPK activation and following cardiomyocyte death, while over-expression of TAK1 facilitated AMPK activation and aggregated cardiomyocyte death