Gene interactions and pathways from curated databases and text-mining

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MAPK12 — STAT5A

Text-mined interactions from Literome

Gaur et al., Blood 2001 : By using avian retroviruses to express wild-type or mutant Mpl on the surfaces of primary megakaryocyte-lineage cells, it was demonstrated that ( 1 ) the 10 membrane-proximal, cytoplasmic amino acids of Mpl are required for TPO induced proliferation ; ( 2 ) Y582F mutation confers a proliferative advantage over wild-type Mpl and imparts a constitutive anti-apoptotic signal ; ( 3 ) truncating the 50 C-terminal Mpl amino acids reduces but does not eliminate TPO induced mitogen activated protein kinase activation, yet it does not alter the synergistic effect of stem cell factor on TPO induced proliferation ; and ( 4 ) TPO induced proliferation of early, primary megakaryocyte-lineage cells does not require Stat-5 phosphorylation
Sadowski et al., J Biol Chem 2001 : Therefore, our results suggest that insulin induction of SOCS-2, and in part SOCS-3 mRNA expression, is mediated by Stat5 and can be independent of mitogen activated protein kinase and phosphatidylinositol 3-kinase signaling pathways
Donato et al., Blood 2001 (Leukemia) : Expression of bcr-abl in interleukin-3 (IL-3)/granulocyte-macrophage colony stimulating factor ( GM-CSF ) -dependent Mo7e cells ( MBA ) resulted in growth factor independence, constitutive activation of Stat-5 phosphorylation, engagement of mitogen activated protein ( MAP ) kinase signals, and increased expression of PTP1B and bcl-x ( L )
Frost et al., Endocrinology 2002 : The tyrosine kinase inhibitors, genistein, PP1, and AG-490, and the MAPK kinase inhibitor, PD98059, did not block Stat3 or Stat5 phosphorylation
Boer et al., Exp Hematol 2003 : In addition, enhanced STAT5 transactivation was independent of the phosphatidyl inositol 3-kinase and MAPK ( p42/p44 ) pathways
Maki et al., J Immunol 2008 : These results demonstrate that MEK1/2 induces TCRgamma germline transcription by phosphorylating STAT5 through IL-7R-FFFF and suggest a potential role for MAPK in IL-7R tyrosine independent activation of STAT5
Williams et al., Blood 2012 (Leukemia) : This aberrant localization was associated with increased STAT5 activation but inhibition of both MAPK and AKT phosphorylation
Wartmann et al., J Biol Chem 1996 : Lactogenic hormone activation of Stat5 and transcription of the beta-casein gene in mammary epithelial cells is independent of p42 ERK2 mitogen activated protein kinase activity