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FAS — MAPK13

Text-mined interactions from Literome

Choi et al., Cancer Res 2001 (Glioblastoma...) : Herein, we demonstrate that : ( a ) stimulation with agonistic anti-Fas monoclonal antibody CH-11 and human recombinant soluble Fas ligand induces expression of the CC chemokine MCP-1 and the CXC chemokine interleukin-8 by human glioma cell lines at the mRNA and protein levels in a dose- and time dependent manner ; ( b ) selective pharmacological inhibitors of MEK1 ( U0126 and PD98059 ) and p38 mitogen activated protein kinase ( MAPK ) ( SB202190 ) suppress Fas mediated chemokine expression in a dose dependent manner ; ( c ) Fas ligation on human glioma cells leads to activation of both extracellular signal regulated kinases ERK1/ERK2 and p38 MAPK ; and ( d ) GBM samples express higher levels of Fas compared with normal control brain, which correlates with increased interleukin 8 expression
Härmälä-Braskén et al., Oncogene 2003 (MAP Kinase Signaling System) : A more physiological inhibitor, the intracellular PP2A inhibitor protein I2 ( PP2A ), protected transfected HeLa cells in a similar way from Fas mediated apoptosis and induced activation of MAPK in I2 ( PP2A ) transfected cells
Menendez et al., Int J Oncol 2004 (Breast Neoplasms) : Strikingly, FAS inhibition also caused a significant activation of the Raf-mitogen activated protein kinase ( MEK ) extracellular signal regulated kinase ( ERK1/2 ) cell survival pathway
Menendez et al., J Cell Biochem 2005 (Neoplasms) : Concurrently, FAS blockade drastically activated MAPK and promoted further a prominent accumulation of HIF-1alpha in Her-2/neu overexpressors
Farley et al., Mol Cell Biol 2006 : Here we show that binding of Fas ligand to Fas activates p38 MAPK in CD8+ T cells and that activation of this pathway is required for Fas mediated CD8+ T-cell death
Park et al., Mol Cancer Ther 2008 (Carcinoma, Hepatocellular...) : In parallel, treatment of cells with MEK1/2 inhibitors and 17AAG caused a p38 MAPK dependent association of caspase-8 with CD95
Park et al., Mol Cancer Ther 2009 (Carcinoma, Renal Cell) : GST-MDA-7 killing was, in parallel, dependent on inactivation of extracellular signal regulated kinase 1/2 and on CD95 induced p38 mitogen activated protein kinase and c-jun NH ( 2 ) -terminal kinase-1/2 signaling
Chen et al., J Cell Biochem 2009 (Calcium Signaling...) : Unlike PLA(2), catalytically inactive PLA(2) treatment did not markedly increase Fas and FasL protein expression, and p38 MAPK activation was exclusively responsible for catalytically inactive PLA(2) induced increase in Fas and FasL protein expression
Kober et al., Cell death & disease 2011 (MAP Kinase Signaling System) : Caspase-8 activity has an essential role in CD95/Fas mediated MAPK activation ... Furthermore, we built a mathematical model describing CD95 DISC mediated MAPK activation and apoptosis
Egle et al., Eur J Immunol 1996 (Multiple Myeloma) : IFN-alpha2 did not alter the Apo-1/Fas induced activity of Mitogen activated protein kinase ( MAPK) 1 and did not inhibit the Apo-1/Fas mediated proteolytic cleavage of ADP-ribosyltransferase, a substrate of Interleukin-beta1 converting enzyme ( ICE ) and homologues
Chauhan et al., Blood 1997 (Multiple Myeloma) : Because interleukin-6 (IL-6) is a growth factor for MM cells and inhibits apoptosis induced by dexamethasone and serum starvation, we examined whether IL-6 affects anti-Fas MoAb induced apoptosis and activation of SAPK or p38 MAPK in MM cells
Salmon et al., J Immunol 1997 : Cross linking of Fas on T cells also induced rapid activation of p38 MAPK and MAPKAP kinase-2 ... We conclude that the activation of p38 MAPK and MAPKAP kinase-2 by cross linking of the TCR, BCR, Fas , or CD40 was not correlated with their roles in regulating lymphocyte survival, and that suppression of kinase activity did not inhibit the induction of apoptosis