Gene interactions and pathways from curated databases and text-mining

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MAPK8 — RELA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Nick et al., J Clin Invest 1999 : Specific inhibitors of p38alpha MAPk blocked LPS induced adhesion, nuclear factor-kappa B (NF-kappaB) activation, and synthesis of tumor necrosis factor-alpha (TNF-alpha)
Haas et al., J Biol Chem 1999 : These cells show a permanent activation of the transcription factor NF-kappaB , exert constitutive p38 mitogen activated protein kinase activity, and produce high amounts of interleukin-6
Liang et al., J Clin Invest 1999 (Cardiomegaly) : p38 MAPK increased hBNP promoter activity through activation of the transcription factor NF-kappaB
Kim et al., FEBS Lett 2000 : This study shows a direct evidence that the SH2-SH2-SH3 region of PLCgamma1 contributes to the NF-kappaB signaling and that MAPK , but not PI3K and PKC, is involved in SH2-SH2-SH3 mediated NF-kappaB activation in these cells
Hippenstiel et al., Blood 2000 : Inhibition of p38 MAPK by SB 202190 also blocked LPS induced NF-kappaB activation and IL-8 synthesis
Jeon et al., J Pharmacol Exp Ther 2000 (MAP Kinase Signaling System) : In contrast, PD98059, a specific inhibitor of mitogen activated protein kinase/extracellular signal regulated protein kinase kinase 1 had no effect on NF-kappaB/Rel activation and iNOS expression
Zhang et al., Cell Immunol 2000 : The results in this paper indicate that LPS induced NF-kappa B binding activity was independent of PKC, PKA, ERK, and p38 MAPK , but was regulated by proteasome
Valladares et al., Endocrinology 2000 : However, TNFalpha induced NF-kappaB DNA binding activity is independent of p38MAPK and ERK activation
Chae et al., Bone 2001 (MAP Kinase Signaling System) : However, the specific inhibitor of p38 MAPK , SB203580, had no effect on TNF-alpha induced NF-kappaB activation and both NF-kappaB inhibitors failed to reduce the p38 MAPK activation in the TNF-alpha stimulated osteoblasts
Castrillo et al., J Biol Chem 2001 : Specific effects on NF-kappa B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK ... The absence of a coordinate activation of MAPK and IKK might contribute to a deficient activation of NF-kappaB that is involved in the anti-inflammatory activity of these molecules
Won et al., Brain Res Mol Brain Res 2001 (Glioma) : In C6 glioma cells, the stimulation with lipopolysaccharide ( LPS ; 1 microg/ml ) evoked increases of nitric oxide ( NO ) production, NO synthase ( iNOS ) mRNA expression, phosphorylation of p38 mitogen activated protein kinase ( p-p38 ), and the activation of NF kappa B
Chae et al., Int Immunopharmacol 2001 : The NF-kappaB inhibitor also transiently activates p38 MAPK but SB203580, a specific p38 MAPK inhibitor, does not have any regulatory effect on PDTC induced cell death, suggesting that the cell death is mediated by JNK not by p38 MAPK
Dreikhausen et al., Eur J Immunol 2001 (MAP Kinase Signaling System) : UDP-monoglucosylation and concomitant inactivation of Rho A and of Rac-2 by Clostridium difficile toxin B also inhibited IL-1 induced activation of JNK and p38 MAPK , but additionally inhibited activation of the extracellular-regulated-kinase pathway and DNA binding of the transcription factor NFkappaB
Liu et al., J Cell Biochem 2001 : Cytokine induced expression of inducible nitric oxide synthase (iNOS) and concomitant production of nitric oxide ( NO ) involve activation of mitogen activated protein ( MAP ) kinases and are in most cases mediated by the transcription factor NF-kappaB
Li et al., J Neurosci Res 2001 (MAP Kinase Signaling System) : Such antiinflammatory effects of vitamin E were correlated with suppression of p38 MAPK and NFkappaB activation and were mimicked by an inhibition of either p38 MAPK ( by SB203580 ) or NFkappaB ( by decoy oligonucleotides )
Bradbury et al., Cancer Res 2001 : In addition, the transient genetic activation of p38 ( MAPK ) inhibited IR induction of NF-kappaB gene expression in the absence of indomethacin
Nakamura et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Analyzing the effects of several inhibitors or mutant receptors revealed that this NF-kappa B activation is mediated neither by MEK/ERK/MAPK nor by the phosphatidylinositol 3-kinase pathway but by STAT5
Dhawan et al., J Biol Chem 2002 (MAP Kinase Signaling System...) : Taken together, our data implicate involvement of I kappa B kinase and MAPK signaling cascades in NIK induced constitutive activation of NF-kappa B
Mendes et al., Nitric Oxide 2002 : The p38MAPK inhibitor, SB 203580, had no effect on IL-1 induced NF-kappaB activation
Roberts et al., Cryobiology 2002 : Inhibition of MAPK with an MEK inhibitor ( PD098059 ) blocked the activation of NF-kappaB but a specific p38 inhibitor ( SB203580 ) had no effect on NF-kappaB
Spiegelman et al., J Biol Chem 2002 (Cell Transformation, Neoplastic) : Activators of mitogen activated protein kinase accelerated IkappaBalpha degradation and increased NF-kappaB transcriptional activity
Xie et al., Blood 2003 : During cell culture, beta ( 2 ) M down-regulated the expression of phosphorylated mitogen activated protein ( MAP ) kinases , extracellular signal related kinase ( ERK ), and mitogen induced extracellular kinase ( MEK ), inhibited nuclear factor-kappaB (NF-kappaB) , and activated signal transducer and activator of transcription-3 ( STAT3 ) in treated cells, all of which are involved in cell differentiation and proliferation
Sanjo et al., Mol Cell Biol 2003 (Fetal Death...) : Recently, serine/threonine kinase TAK1 and TAK1 binding protein 1 and 2 (TAB1/2) have been identified as molecules involved in IL-1 induced TRAF6 mediated activation of AP-1 and NF-kappa B via mitogen activated protein ( MAP ) kinases and I kappa B kinases, respectively
Schiekofer et al., Diabetes 2003 (Hyperglycemia) : Inhibition of activation of ras, MAPK , or protein kinase C blocked hyperglycemia mediated NF-kappaB activation in ex vivo isolated PBMCs stimulated with 10 mmol/l glucose
Parhar et al., Immunology 2003 : However, the precise inter-relationship between the activation of p38 MAPK and activation of the transcription factor NF-kappaB in the intestinal epithelial cell ( IEC ) system, remains unknown ... It is concluded that p38 MAPK influences the expression of chemokines in intestinal epithelial cells, through an effect upon the activation of the chemokine promoter, and does not directly involve the activation of the transcription factor NF-kappaB
Chae et al., Res Commun Mol Pathol Pharmacol 2001 : However, a specific inhibitor of p38 MAPK , SB203580, had no effect on TNF-alpha/IFN-gamma or LPS/IFN-gamma induced NF-kappaB activation
Kang et al., Toxicol Appl Pharmacol 2003 : These data suggest that FeTMPyP downregulates the proliferative activity by inhibition of p38 MAPK activation, NF-kappaB activation , and IL-2 secretion during mitogenic stimulation of thymocytes
Deva et al., J Immunol 2003 (MAP Kinase Signaling System) : That NF-kappaB up-regulates p38 ( MAPK ) is novel and is in contradiction to earlier reports in which NF-kappaB was shown to inhibit p38 ( MAPK )
Pauleau et al., Mol Cell Biol 2003 : Macrophages responded normally to multiple Toll-like receptor agonists in terms of NF-kappaB target activation, mitogen activated protein kinase activation , and cytokine secretion
Le Page et al., Biol Chem 2003 (Inflammation) : In RAW264.7 macrophages the inducers of NF-kappaB activate the production of reactive oxygen species and three mitogen activated protein kinases ( MAPK ), the extracellular signal regulated kinase ( ERK ), the c-jun N-terminal kinase/stress activated protein kinase ( JNK ), and p38
Ma et al., J Immunol 2004 : Studies conducted to understand the regulation of AP-1 and NF-kappaB activation by JNK MAPK revealed that both DXM and SP600125 inhibited IL-12p40 gene transcription by inhibiting the activation of AP-1 and NF-kappaB transcription factors as revealed by luciferase reporter and gel mobility shift assays
Wu et al., Biochem J 2004 : Proteasome inhibitors up-regulate haem oxygenase-1 gene expression : requirement of p38 MAPK ( mitogen activated protein kinase ) activation but not of NF-kappaB ( nuclear factor kappaB ) inhibition
Matsuyama et al., J Immunol 2004 : p38 MAPK was critical for DDR1b mediated, increased NF-kappaB trans-activity, but not for IkappaB degradation or NF-kappaB nuclear translocation, suggesting a role for p38 MAPK in the modification of NF-kappaB
Jefferies et al., Immunol Lett 2004 : Further investigation into the role of Btk in LPS signalling has directly implicated Btk downstream of TLR4, both with respect to p38 MAPK activation and activation of the transcription factor NFkappaB
Zoja et al., Curr Opin Nephrol Hypertens 2004 (Disease Progression...) : Albumin endocytosis in proximal tubular cells triggers events that include protein kinase C-dependent generation of reactive oxygen species, nuclear translocation of NF-kappaB , and activation of mitogen activated protein kinase
Je et al., FEBS Lett 2004 (MAP Kinase Signaling System) : HHE increased the activity of p38 MAPK and extracellular signal regulated kinase ( ERK ), but not c-jun NH ( 2 ) -terminal kinase, indicating that p38 MAPK and ERK are closely involved in HHE induced NF-kappaB transactivation ... These findings strongly suggest that HHE induces NF-kappaB activation through IKK/NIK pathway and/or p38 MAPK and ERK activation associated with oxidative stress in endothelial cells
Shan et al., J Biol Chem 2004 : Inhibition of NF-kappaB , and the activation of p38 MAPK were also found to be involved in 15d-PG J2-induced chondrocyte apoptosis
Hsieh et al., Cell Signal 2004 (MAP Kinase Signaling System) : In accordance with these findings, BK-induced phosphorylation of p42/p44 MAPK and Akt and activation of NF-kappaB was attenuated by prior treatment with PD98059, LY294002, and helenalin, respectively
Rahman et al., Am J Physiol Lung Cell Mol Physiol 2004 : Because p38 MAPK can induce transcriptional activity of RelA/p65 without altering the DNA binding function of NF-kappaB, we addressed the possibility that cAMP antagonizes thrombin induced NF-kappaB activity and ICAM-1 expression by preventing the activation of p38 MAPK
Zhao et al., J Neuroimmunol 2004 (MAP Kinase Signaling System) : 15d-PGJ2 inhibited transactivation of NF-kappaB dependent promoters, as well as p38 and JNK MAPK phosphorylation induced by IL-1, while having no inhibitory effect on IFN induced Stat signaling pathways
Khan et al., Immunology 2004 : Finally, we demonstrated that pharmacological inhibition of p38 MAPK reduced IL-8 transcription and mRNA levels, but did not affect NF-kappaB activation
Sée et al., J Cell Biol 2004 (Calcium Signaling...) : Inhibition of the MAPK- but not the PtdIns3K dependent pathway inhibited NF-kappaB signaling, and further, CD1 transcription and cell cycle progression
Campbell et al., J Immunol 2004 (Arthritis, Rheumatoid) : This is mediated through p38 MAPK regulation of NF-kappaB
Lamkanfi et al., J Biol Chem 2005 : Structure-function analysis shows that NF-kappaB activation occurs independent of enzymatic activity of the protease and that the caspase recruitment domain of caspase-2 is sufficient for the activation of NF-kappaB and p38 MAPK
Ku et al., Immunol Rev 2005 (Ectodermal Dysplasia...) : In these subjects, the NF-kappaB- and mitogen activated protein kinase mediated induction of inflammatory cytokines in response to TIR agonists is impaired
Vega-Ostertag et al., Arthritis Rheum 2005 : Our data show that aPL induces significant increases in TF transcription, function, and expression, in IL-6 and IL-8 up-regulation, and in iNOS expression on HUVECs and that these processes involve phosphorylation of p38 MAPK and activation of NF-kappaB
Rath et al., Biochim Biophys Acta 2005 (Burkitt Lymphoma) : The expression of IkappaB-alphaDN protein did not inhibit the constitutive NF-kappaB activity, but it inhibited cell proliferation, antiproliferative response to IFN-alpha, and phosphorylated mitogen activated protein kinase ( p-MAPK ) level
Tokuda et al., Connect Tissue Res 2005 : As shown by electrophoretic mobility shift assay p38 MAPK was not involved in SP-induced activation of nuclear factor-kappa B (NF-kappaB)
Saatian et al., Biochem J 2006 : Similarly, JNK ( i ) II only blocked LPA mediated phosphorylation of JNK and c-Jun, AP-1 transcription and IL-8 promoter mediated luciferase reporter activity, without blocking p38 MAPK dependent NF-kappaB transcription
Mashima et al., J Biol Chem 2005 : The forced expression of FLN29 in macrophage-like RAW cells resulted in the suppression of TLR mediated NF-kappaB and mitogen activated protein kinase activation , while a reduced expression of FLN29 by small interfering RNA partly cancelled the down-regulation of LPS signaling
Kim et al., Int Immunol 2005 (MAP Kinase Signaling System) : Moreover, inhibitors of MAPK ( U0126 and SB203580 ) significantly reduced the IL-8 production, while the inhibition of NF-kappaB ( pyrrolidinedithiocarbamate and retrovirus containing dominant negative IkappaB alpha plasmid ) did not affect the IL-8 expression increased by CpG ODN
Chandrasekar et al., Biochem Biophys Res Commun 2006 : IL-18 induced activation of NF-kappaB and PTEN upregulation were mediated by p38MAPK
Krüll et al., Am J Respir Cell Mol Biol 2006 : In addition, the chemical inhibitor as well as dominant negative mutants of p38 MAPK isoforms p38alpha, beta2, and gamma inhibited C. pneumoniae related NF-kappaB activation ... Our data demonstrate that C. pneumoniae triggers an early proinflammatory signaling cascade involving p38 MAPK dependent NF-kappaB activation, resulting in subsequent GM-CSF release
Wu et al., Kidney Int 2006 : P-p42/44 MAPK blockade inhibited the CTGF induced expression of P-p42/44 MAPK but not NF-kappaB , and partially decreased the levels of the above chemokines in supernatants
Kang et al., Toxicological sciences : an official journal of the Society of Toxicology 2006 : In the present study, we investigated whether Src family TKs play a role in crystalline silica induced NF-kappaB activation and whether NF-kappaB activation requires Src TK-dependent MAPK activity in RAW 264.7 cells, a mouse peritoneal macrophage cell line
Chae et al., Immunopharmacol Immunotoxicol 2005 : However, a specific inhibitor of p38 MAPK , SB203580, had no effect on the NF-kappaB activation, and both the NF-kappaB inhibitors failed to reduce the p38 MAPK activation in the IL-1beta stimulated HGFs
Aeberli et al., FEBS Lett 2006 (MAP Kinase Signaling System) : This is associated with increased expression of mitogen activated protein kinase ( MAPK ) phosphatase-1 ( MKP-1 ), concomitant decreased phosphorylation of p38 MAPK , but no effect of MIF on nuclear factor kappaB (NF-kappaB)
Uesugi et al., Brain Res 2006 : These results suggest that both MKK3/6-p38MAPK and MKK4-JNK pathways are important signaling cascades leading to the induction of TNFalpha in LPS stimulated microglia, but that NFkappaB itself is not required for this induction
Syeda et al., J Biol Chem 2006 : Activation of PAR-1 or PAR-2 promoted nuclear translocation and phosphorylation of p65-NF-kappaB, and thrombin induced but not PAR-2 induced p65-NF-kappaB phosphorylation was reduced by inhibition of MEK or p38MAPK
Shan et al., Am J Physiol Lung Cell Mol Physiol 2006 (Asthma...) : Finally, activation of p38 MAPK with anisomycin prevented both the LPS induced stimulation of ERK1/2 mediated NF-kappaB activity and associated changes in ASM responsiveness
Sunahori et al., Arthritis Res Ther 2006 (Arthritis, Rheumatoid) : NF-kappaB activation was induced in S100A8/A9 stimulated monocytes, but this activity was not inhibited by p38 MAPK inhibitors
Tang et al., J Am Soc Nephrol 2006 (Diabetic Nephropathies...) : Also in a dose dependent manner, GA ( 0.5 mg/ml ) but not albumin caused nuclear translocation of NF-kappaB and activation of mitogen activated protein kinase ( MAPK ) p44/p42 and signal transducer and activator of transcription ( STAT-1 )
Kefaloyianni et al., Cell Signal 2006 (MAP Kinase Signaling System) : ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts
Calleros et al., Cell Signal 2006 (MAP Kinase Signaling System) : Here, we found that inhibition of p38 MAPK with the specific inhibitor SB203580 blocked the increase in NFkappaB activity, IkappaBalpha degradation and p65/NFkappaB translocation to the nucleus induced by cholesterol depletion
Kuo et al., Oncogene 2007 : Furthermore, 32D/IRS-1/ALK cells display an enhanced activation of mitogen activated protein kinase and PI3-kinase pathways, and a selective transcriptional activation of nuclear factor (NF)-kappaB
Kang et al., Toxicol Appl Pharmacol 2006 : These results suggest that the 5d-PGJ2 induced OK cell death was associated with ROS production and NF-kappaB inhibition , but not with MAPK activation
Westra et al., Mini Rev Med Chem 2006 (Arthritis, Rheumatoid) : In this review new insights such as non-stressful activation of p38 MAPK, and the role of p38 MAPK in regulation of NF-kappaB recruitment are also discussed
Bamford et al., Cell Microbiol 2007 (Burkholderia Infections) : Highly purified lipopolysaccharides from Burkholderia cepacia complex clinical isolates induce inflammatory cytokine responses via TLR4 mediated MAPK signalling pathways and activation of NFkappaB
Kweon et al., Biochem Biophys Res Commun 2006 (Inflammation...) : Synergistic activation of NF-kappaB by nontypeable H. influenzae and S. pneumoniae is mediated by CK2, IKKbeta-IkappaBalpha, and p38 MAPK
Guo et al., Peptides 2006 (MAP Kinase Signaling System) : These results also demonstrate that Ang II leads to MAPK phosphorylation and p38MAPK pathway induced NF-kappaB activation
Kaushal et al., J Neurosci 2007 (Neurodegenerative Diseases) : Microglia activation involved the signaling pathways p38 mitogen activated protein kinase ( MAPK ) and nuclear factor kappaB (NF-kappaB), which are important for upregulation of numerous proinflammatory molecules, and the KCa3.1 channels were functionally linked to activation of p38 MAPK but not NF-kappaB
Kanda et al., Endocrinology 2007 (MAP Kinase Signaling System...) : Inhibitors of Janus kinase ( JAK ), p38 MAPK, and MAPK/ERK kinase (MEK) suppressed prolactin- plus IFN-gamma induced CXCL9, CXCL10, and CXCL11 production and NF-kappaB , STAT1, and IRF-1 activities
Kanda et al., Eur J Immunol 2007 : Inhibitors of PI3 K, p38 MAPK , and MEK suppressed IL-18 plus IFN-gamma induced CXCL9, CXCL10, and CXCL11 production and NF-kappaB , STAT1, and IRF-1 activities
Zhi et al., J Leukoc Biol 2007 (Inflammation) : We also found that H2S stimulated the phosphorylation and activation of ERK1/2, but not of p38 MAPK and JNK, and pretreatment with PD98059, a selective MEK1 antagonist, could inhibit H2S induced NF-kappaB activation markedly
Hou et al., Arch Biochem Biophys 2007 : The results demonstrated that PDGG suppressed COX-2 expression via blocking MAPK mediated activation of nuclear factor-kappaB (NF-kappaB) , activator protein-1 (AP-1) and C/EBPdelta
Tirumurugaan et al., Am J Physiol Lung Cell Mol Physiol 2007 (MAP Kinase Signaling System) : We determined the role of mitogen activated protein kinase ( MAPK ) in the activation of NF-kappaB and AP-1 in the regulation of CD38 expression in HASM cells
Lee et al., Carcinogenesis 2007 (MAP Kinase Signaling System) : The roles of extracellular signal regulated protein kinase-1/2 and p38 MAPK in TPA induced activation of NF-kappaB in mouse skin had been defined in our previous studies
Hong et al., Life Sci 2007 : These results suggest that EGCG may exert an anti-inflammatory effect in endothelial cells by controlling MCP-1 expression, at least in part, mediated through the suppression of p38 MAPK and NF-kappaB activation
Kundu et al., Ann N Y Acad Sci 2007 : Taken together, EGCG inhibited TPA induced DNA binding of NF-kappaB and CREB by blocking activation of p38 MAPK , which may provide a molecular basis of COX-2 inhibition by EGCG in mouse skin in vivo
Lim et al., Life Sci 2007 : Since p38 MAPK can activate NF-kappaB , we made point mutations in the NF-kappaB binding site within the COX-2 promoter
Lee et al., Cardiovasc Res 2007 : Down-regulation of NQO1 inhibits MMP-9 gene expression by suppressing activation of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1), well-known key elements mediating MMP-9 gene expression in its promoter, via the p38 MAPK and JNK pathways
Haugen et al., Endocrinology 2007 : NF-kappaB activation by globular adiponectin was not affected by antibody inhibition of toll-like receptor 4 or TNF receptors 1 and 2 but was attenuated by inhibitors of p38 MAPK , phosphatidylinositol 3-kinase, and protein kinase C. Analyses of the p65 subunit of NF-kappaB in different leukocyte cell lines showed activation of two monocytic cell lines ( U937 and THP-1 ) by native and globular adiponectin
Suzuki et al., J Cell Physiol 2008 (Hemorrhage) : Two hrs thereafter, Kupffer cells and SMPhi production of IL-6, TNF-alpha, and IL-10, activation of MAPK ( p38, ERK-1/2, and JNK ), and transcription factors ( NF-kappaB and AP-1 ) were determined
Ishizuka et al., J Pharmacol Exp Ther 2008 : It seems that 20-HETE triggers NF-kappaB and MAPK/ERK activation and that both signaling pathways participate in the cellular mechanisms by which 20-HETE activates vascular endothelial cells
Lewis et al., J Invest Dermatol 2008 : UVB induced activation of NF-kappaB is regulated by the IGF-1R and dependent on p38 MAPK
Zhao et al., J Cardiovasc Pharmacol 2008 : Our findings suggest that aspirin can decrease inflammatory responses induced by ox-LDL, and the mechanism might be associated with NF-kappaB activation pathway and inhibition of p38 MAPK phosphorylation
Zabalgoitia et al., Free Radic Biol Med 2008 : HO-1 overexpression, HO-1 induction, or treatment with heme metabolites all reverse IL-18 mediated p38alpha MAPK and NF-kappaB activation , PTEN induction, Akt suppression, and EC death
Khan et al., Infect Immun 2008 (Enterobacteriaceae Infections...) : These responses were accompanied by mitogen activated protein kinase activation, as well as the Toll-like receptor 5 (TLR5) dependent activation of NF-kappaB
Xu et al., Respir Res 2008 (Haemophilus Infections...) : However, NTHi induced DNA binding activity of NF-kappa B was not affected by the inhibition of p38 MAPK
Küenzi et al., Apoptosis 2008 : Application of equal concentrations of MiliA to other cells such as the murine neuroblastoma cell line N2a resulted in immediate onset of apoptosis by nuclear translocation of apoptosis inducing factor ( AIF ), activation of caspases and c-Jun/AP-1 transcription factor without an intermediate differentiated phenotype, although minor transient phosphorylation of PKB and MAPK as well as activation of NF-kappaB were also observed
Liu et al., Eur J Pharmacol 2008 (Disease Models, Animal...) : These data suggest that p38MAPK signaling may be involved in the activation of NF-kappaB , and activation of p38MAPK signaling may be one of the mechanisms of acute lung injury
Hisatsune et al., J Immunol 2008 : Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation
Yao et al., Am J Physiol Lung Cell Mol Physiol 2008 (Pneumonia) : The mouse strain that was more susceptible to effects of CS showed augmented lung inflammatory cell influx, activation of NF-kappaB and p38 MAPK , and increased levels of matrix metalloproteinase-9 and NF-kappaB dependent proinflammatory cytokines compared with resistant mouse strains
Lee et al., Cell Res 2008 : The inhibition of p38 MAPK and JNK/SAPK blocked NF-kappaB activation
Hickey et al., J Leukoc Biol 2008 : CyaA enhanced LPS induced phosphorylation of p38 MAPK and ERK in DC, and inhibitors of p38 MAPK, MEK, or NF-kappaB suppressed IL-10 production in response to LPS and CyaA
Ben-Othman et al., Mol Immunol 2008 (Leishmaniasis...) : This impairment was not due to MAPK deactivation as inhibition of ERK1/2 and p38MAPK , actually enhances the transcriptional activity of NF-kappaB in response to initial contact of Leishmania with the murine macrophagic cell line Raw264.7
Martín-Vilchez et al., Br J Pharmacol 2008 (Hepatitis C) : AM3 triggered nuclear translocation of NF-kappaB and phosphorylation of p38 mitogen activated protein kinase
Min et al., Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008 (MAP Kinase Signaling System...) : SNP induced the phosphorylation of p38 MAPK and extracellular regulated kinase (ERK), degradation and phosphorylation of IkappaB, and activation of NF-kappaB
Rodríguez-Calvo et al., Diabetes 2008 : Because mitogen activated protein kinase-extracellular signal related kinase ( ERK ) 1/2 ( MEK1/2 ) is involved in LPS induced NF-kappaB activation in adipocytes, we explored whether PPARbeta/delta prevented NF-kappaB activation by inhibiting this pathway
Zare et al., J Leukoc Biol 2008 : In contrast, Plg production did not require NF-kappaB , was only partly down-regulated by p38 MAPK inhibitor, and was efficiently inhibited by insulin, indicating a different mechanism for its induction
Liu et al., Invest Ophthalmol Vis Sci 2008 : Poly ( I:C ) induces the up-regulation of TLR3, the MAPK dependent expression of proinflammatory cytokines, chemokines, and adhesion molecules and the activation of NF-kappaB in human corneal fibroblasts
O'Sullivan et al., J Surg Res 2009 (Inflammation) : The role of P38 MAPK and PKC in BLP induced TNF-alpha release, apoptosis, and NFkappaB activation in THP-1 monocyte cells
Zhou et al., World J Gastroenterol 2008 (Adenocarcinoma...) : Viable LBG or LBG- ( s ) pretreatment attenuated the expression of TLR4, inhibited the phosphorylation of TAK1 and p38MAPK , prevented the activation of NF-kappaB , and consequently blocked IL-8 production
Lee et al., J Mol Med (Berl) 2009 : These results suggest that p38 MAPK may lead to the activation of IKK and NF-kappaB signaling, resulting in enhanced DC maturation and CXCL2 expression in response to C. difficile toxin A stimulation
Dragomir et al., Thromb Haemost 2008 : The MAPK inhibitors blocked the phosphorylation of IkBalpha and c-jun, indicating the role of MAPK in NF-kappaB and AP-1 activation in SMC under HG conditions
Kim et al., J Cell Physiol 2009 (Calcium Signaling...) : NECA induced increase of nuclear factor (NF)-kappaB phosphorylation was inhibited by MAPK inhibitors
Jung et al., Food Chem Toxicol 2009 (Inflammation) : The molecular mechanisms that underlie GHE mediated attenuation are related to the inhibition of the phosphorylation of three mitogen activated protein kinases ( MAPKs ), extracellular signal regulated kinases 1 and 2 ( ERK1/2 ), p38 MAPK , and c-Jun N-terminal kinase (JNK), and the activation of nuclear factor-kappaB (NF-kappaB)
Hu et al., Am J Physiol Cell Physiol 2009 : PD-98059 blocked IL-1beta induced phosphorylation of IKK2, degradation of IkappaB-alpha, and phosphorylation and nuclear translocation of NF-kappaB subunit p65, whereas SB-203580 had a marginal effect, implying that the effect of ERK1/2 is exerted on the canonical IKK2/IkappaB-alpha/p65 pathway of NF-kappaB activation but that the effect of p38 MAPK may not predominantly involve NF-kappaB signaling
Feng et al., Eur J Pharmacol 2009 (Disease Models, Animal...) : Glial activation markers such as macrophage antigen complex-1 ( mac-1 ) and glial fibrillary acidic protein (GFAP), interleukin (IL)-1beta and IL-6, nuclear factor-kappa B (NF-kappaB) activation , and p-p38 mitogen activated protein kinase ( MAPK ) activation in the lumbar spinal cord were determined as well
Hsieh et al., Neurotox Res 2010 : Taken together, these results suggested that in RBA-1 cells, activation of NF-kappaB by a c-Src dependent PI3K/Akt-p42/p44 MAPK activation mediated through transactivation of PDGFR is essential for MMP-9 gene upregulation induced by LTA
Shih et al., Eur J Immunol 2009 (Inflammatory Bowel Diseases) : TL1A induced by bacteria is mediated in part by the TLR signaling pathway and inhibited by downstream blockade of p38 MAPK and NF-kappaB activation
Yu et al., J Biol Chem 2009 (Inflammation...) : In addition, IDR-1 induced p38 MAPK activity in a p62 dependent manner and increased CCAAT-enhancer binding protein beta activity, whereas NF-kappaB activity was unaffected
Khan et al., Mol Cell Biochem 2010 (Escherichia coli Infections...) : In this article, we have shown that EAEC induced activation of mitogen activated protein kinases ( MAPK ) ( ERK-1/2, JNK and p38MAPK ) in cultured human intestinal epithelial cells ( INT-407 ) leads to the induction of DNA binding activity of NF-kappaB and AP-1, resulting in IL-8 production
Kim et al., Neurochem Int 2010 (Parkinson Disease) : These results collectively suggest that ROS, PI3 kinase, NF-kappaB , and AP-1 are commonly involved in 6-OHDA- and MPP ( + ) -induced MMP-9 gene expression, and that p38 MAPK is differentially involved
Yang et al., Curr Cancer Drug Targets 2009 (Neoplasms) : In the second part, the mechanisms by which Gadd45 proteins are regulated by NF-kappaB , and how they affect MAPK activation, are reviewed
Chen et al., Chem Biol Interact 2010 : Nitrosative stress induces osteoblast apoptosis through downregulating MAPK mediated NFkappaB/AP-1 activation and subsequent Bcl-X ( L ) expression
Seo et al., Curr Eye Res 2010 (Dacryocystitis...) : Furthermore, DA-6034 attenuated the phosphorylation of JNK and p38 MAPK and inhibited NF-kB activation in a concentration dependent manner in corneal epithelial cells
Yang et al., Atherosclerosis 2010 : N-acetylcysteine, SP600125 ( JNK inhibitor ) and SB203580 ( p38 MAPK inhibitor ) attenuated TNF-alpha induced DNA binding activities of both AP-1 and NF-kappaB
Twait et al., Pancreatology 2010 (Pancreatitis) : Dominant negative p38 mitogen activated protein kinase expression inhibits NF-kappaB activation in AR42J cells
Wang et al., Mucosal Immunol 2010 : Induction of MKP-1 is blocked by inhibitors of nuclear factor (NF)-kappaB , but not of MAPK
Duan et al., Int Immunopharmacol 2010 (Acute Lung Injury...) : Pretreatment with MDMP dampened LPS induced inflammatory responses in RAW264.7 cells, including down-regulation of TLR4-MD-2 complex on the cell surface, suppression of LPS binding to the cells, inhibition of mitogen activated protein kinase ( MAPKs ) and nuclear factor kappa B (NF-kappaB) activation , reduction of tumor necrosis factor-alpha (TNF-alpha) production
Bae et al., Int Immunopharmacol 2010 : To assess the effects of sauchinone on LPS induced macrophages activation, we measured the production of tumor necrosis factor (TNF)-alpha and macrophage inflammatory protein (MIP)-2, and activation of mitogen activated protein kinases ( MAPKs ) including extracellular signal regulated kinase ( ERK ) 1/2, c-Jun amino terminal kinases and p38 mitogen activated protein kinase , and NF-kappaB activation in RAW264.7 cells
Wang et al., Zhonghua Gan Zang Bing Za Zhi 2011 (Carcinoma, Hepatocellular...) : p38 MAPK inhibitor ( SB203580 ) could significantly inhibit IL-8 production in a dose dependent manners ( F = 65.47, P < 0.01 ), and partially inhibited NF-kB p65 nuclear translocation in a dose dependent manner ( F=141.20, P < 0.05 )
Koong et al., Cancer Res 1994 : Furthermore, although conditions of low oxygen can also activate mitogen activated protein kinases ( ERK1 and ERK2 ), these kinases do not appear to be involved in regulating NF-kappa B by low oxygen conditions, as dominant negative mutants of mitogen activated protein kinase do not inhibit NF-kappa B activation by hypoxia
Sonoda et al., J Biol Chem 1997 : Possible role of mitogen activated protein kinase on the okadaic acid induced NF-kappaB activation
Li et al., J Biol Chem 1997 : In hyperoxia, NF-kappaB regulation was independent of mitogen activated protein kinase ( MAPK )
Schwenger et al., Mol Cell Biol 1998 : Recent evidence indicated that NaSal activates the p38 mitogen activated protein kinase ( MAPK ), raising the possibility that inhibition of NF-kappaB activation by NaSal is mediated by p38 MAPK
Lee et al., Proc Natl Acad Sci U S A 1998 : We have previously shown that mitogen activated protein kinase/ERK kinase kinase 1 ( MEKK1 ) can induce both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight IkappaB kinase complex in vitro
Craxton et al., J Immunol 1998 (Lymphoma, B-Cell) : We have investigated the activation of the p38 MAPK pathway in response to CD40 engagement in multiple B cell lines and in human tonsillar B cells to define the role of p38 MAPK in proliferation, NF-kappaB activation and gene expression
Sánchez-Mejorada et al., J Biol Chem 1998 : Using the specific MAPK/extracellular signal regulated kinase kinase ( MAPK kinase ) inhibitor PD98059, we found that MAPK activation is necessary for FcR dependent activation of the nuclear factor NF-kappaB