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MFNG — NOTCH1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yang et al., Mol Biol Cell 2005
:
Here, we report that expression of mammalian fringe proteins ( Lunatic [LFng ], Manic
[MFng ], or Radical [RFng ] Fringe )
increased Delta1 binding and activation of
Notch1 signaling in 293T and NIH 3T3 cells
Hou et al., J Biol Chem 2012
:
In mutant Chinese hamster ovary ( CHO ) cells that do not add galactose (Gal) to the GlcNAc transferred by Fringe, JAG1 induced
NOTCH signaling is not
inhibited by LFNG or
MFNG ... By contrast,
MFNG promoted DLL1 induced
NOTCH signaling better in the absence of Gal than in its presence ... Gal enhances the effect of LFNG but inhibits the
effect of
MFNG on DLL1 induced
NOTCH signaling, with functional consequences for regulating the strength of NOTCH signaling
Gu et al., PloS one 2012
(Asthma...) :
Notch signaling was more activated in asthmatic naïve CD4 ( + ) T cells than in control cells, and Lfng, but not
Mfng or Rfng, partly
inhibited Notch signaling in asthmatic naïve CD4 ( + ) T lymphocytes