Gene interactions and pathways from curated databases and text-mining

◀ Back to IGF1

IGF1 — MLST8

Text-mined interactions from Literome

Cybulski et al., Proc Natl Acad Sci U S A 2009 (Fatty Liver) : mTORC2 , which consists of rictor, mSIN1, mLST8, and mTOR, is activated by insulin/IGF1 and phosphorylates Ser-473 in the hydrophobic motif of Akt/PKB
Burgos et al., Domest Anim Endocrinol 2010 : In addition, IGF-1 stimulated mTORC1 kinase activity toward 4E-BP1 in vitro
Dennis et al., J Biol Chem 2013 : These findings were extended to a cell culture system wherein loss of 4E-BP1 and 4E-BP2 resulted in elevated interaction of p70S6K1 with IGF1 induced activation of mTORC1 in conjunction with an enhanced rate of p70S6K1 phosphorylation at Thr-389
Melnik et al., Hautarzt 2013 (Acne Vulgaris...) : mTORC1 , the central hub of protein- and lipid biosynthesis, cell growth and proliferation, is activated by insulin, IGF-1 and branched-chain essential amino acids, especially leucine ... mTORC1 , the central hub of protein- and lipid biosynthesis, cell growth and proliferation, is activated by insulin, IGF-1 and branched-chain essential amino acids, especially leucine