Gene interactions and pathways from curated databases and text-mining

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CAPN5 — MMP15

Text-mined interactions from Literome

Li et al., Diabetes 2011 (Cardiomyopathy, Hypertrophic...) : In cultured cardiac fibroblasts, high glucose induced proliferation and MMP activities were prevented by calpain inhibition
Subramanian et al., J Cardiovasc Pharmacol 2012 (Aortic Aneurysm, Abdominal...) : Inhibition of calpain , a calcium activated neutral cysteine protease, by overexpression of its endogenous inhibitor, calpastatin, attenuates AngII induced leukocyte infiltration, perivascular inflammation, and MMP activation in mice
Singh et al., Can J Physiol Pharmacol 2012 (Anoxia...) : On the other hand, inhibition of calpain activity upon treatment with leupeptin or MDL 28170 significantly reduced the MMP activity in addition to attenuating the I/R induced alterations in cardiac function and Na ( + ) /K ( + ) -ATPase activity