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MMP2 — NOS2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Keilhoff et al., Dev Neurobiol 2007
(Sciatic Neuropathy...) :
Compared with uninjured and PBS treated injured nerves, the minocycline treated injured nerve showed : ( i ) a decrease in macrophage recruitment and activation, probably resulting from inhibition of blood-brain-barrier break-down via reduced
MMP2 and MMP9 induction, inhibition of revascularization via additional reduction of VEGF induction, and
inhibition of
inducible NO synthase (iNOS) induction ; ( ii ) reduced activation of phagocytic Schwann cells, probably by inhibition of iNOS, MMP2 and MMP9 expression ; ( iii ) a slowed Wallerian degeneration ; and subsequently, ( iv ) a diminished nerve regeneration
Chen et al., Toxicological sciences : an official journal of the Society of Toxicology 2008
(Lung Neoplasms...) :
Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion, and metastasis via
iNOS mediated
MMP-2 production ... Using a mouse model, we showed that gNO promoted A549 metastasis to the lung through a mechanism involving the
iNOS dependent
MMP-2 activity
Chen et al., Tokai J Exp Clin Med 2008
(Plaque, Atherosclerotic) :
Activation of inducible
nitric oxide synthase increases
MMP-2 and MMP-9 levels in ApoE-knockout mice
Givvimani et al., International journal of physiology, pathophysiology and pharmacology 2011
:
Hcy increases
iNOS ,
activates matrix metalloproteinase ( MMP ) , disrupts connexin-43 and increases collagen/elastin ratio
Souza-Pinto et al., J Biomed Mater Res A 2013
(Inflammation) :
Inducible
nitric oxide synthase inhibition
increases MMP-2 activity leading to imbalance between extracellular matrix deposition and degradation after polypropylene mesh implant ...
NOS2 inhibition
increased MMP-2 activity and resulted in a higher visceral adhesion incidence at the mesh implantation site when compared with non treated animals that underwent the same procedure