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IL1A — MMP8

Text-mined interactions from Literome

Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha) , macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Lotz et al., Rheum Dis Clin North Am 1999 (Arthritis...) : NO also may be involved as a mediator of IL-1 induced expression of MMP , mRNA, and protein and may contribute as an activator of the latent forms of the enzymes
van Meurs et al., J Immunol 1999 (Arthritis...) : In vitro studies showed that SLN-1 is also pivotally involved in IL-1 induced MMP activity
Origuchi et al., Clin Exp Rheumatol 2000 (Arthritis, Rheumatoid) : In support of this result, IL-1 beta stimulation induced the expression of membrane type matrix-metalloproteinase ( MT-MMP ), a newly identified MMP-2 specific activator, in rheumatoid osteoblasts
Hui et al., Ann Rheum Dis 2001 : IGF1 can also down regulate IL1alpha or IL1alpha + OSM induced MMP-1, MMP-3, MMP-8 , and MMP-13 mRNA expression in human articular chondrocytes and bovine chondrocytes
Shlopov et al., J Rheumatol 2001 (Osteoarthritis) : A decrease in IL-1alpha , IL-1beta, and IL-6 would reduce stimulation of MMP production, while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves
Miyajima et al., Microb Pathog 2001 (Corneal Ulcer...) : Effects of pseudomonal virulence factors [ elastase, alkaline protease, exotoxin A and lipopolysaccharide (LPS) ], tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta on MMP induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ), zymography and immunoblotting
Elliott et al., Arthritis Res Ther 2003 (Bone Neoplasms...) : To quantify the effects of CDDO on IL-1 induced MMP-1, MMP-13 and Bcl-3 expression, we stimulated the chondrosarcoma cell line SW-1353 and human primary chondrocytes with IL-1, in the presence or absence of CDDO
Kaden et al., Atherosclerosis 2003 (Aortic Valve Stenosis) : As recent studies have suggested that calcific AS might result from an inflammatory process involving leukocyte invasion and activation, the present study aimed to elucidate the role of the pro-inflammatory cytokine interleukin (IL)-1 beta on MMP expression and cell proliferation in human aortic valves
Smith et al., Br J Ophthalmol 2004 : IL-1alpha and LPS had no effect on MMP/TIMP production by cultured corneal epithelial cells and keratocytes
Dayer et al., Reumatismo 2004 (Arthritis, Rheumatoid) : IL-1 and TNF-alpha are potent inducers of matrix metalloproteinases ( MMP ) , eicosanoids, nitric oxide oxydase ( iNOS ), receptor activator of NF-kB ligand ( RANKL ), products involved in the destruction of the extracellular matrix, the cartilage and in bone resorption
Kobayashi et al., Arthritis Rheum 2005 (Osteoarthritis, Knee) : Independent analyses of gene expression in cultured cartilage from 9 other OA patients revealed that IL-1 or TNFalpha blockade, either alone and/or in combination, frequently down-regulated MMP-1, MMP-3 , and MMP-13 expression
Wilusz et al., J Orthop Res 2008 : We used an in vitro model system to examine the hypotheses that acute exposure to IL-1 inhibits meniscal repair, and that an IL-1 mediated increase in matrix metalloproteinase ( MMP ) activity is associated with the inhibition of repair
McNulty et al., Clin Orthop Relat Res 2009 : In the presence of IL-1 , the broad-spectrum MMP inhibitor GM 6001 decreased the MMP activity in the media, increased the shear strength of repair, and enhanced tissue repair in the interface
McNulty et al., Osteoarthritis Cartilage 2010 (Knee Injuries) : IL-1 increased MMP activity, S-GAG release, and NO production, while decreasing the shear strength and tissue repair in the interface
Lemke et al., Cell Tissue Res 2010 (Arthritis) : Significant IL-1 effects were a decrease in biosynthetic activity, an increase in GAG release and in the expression/abundance of MMP-2, MMP-3 and ADAMTS4
Litherland et al., J Biol Chem 2010 : However, MMP1 and MMP13 induction by IL-1 + OSM was inhibited only by aPKC silencing, suggesting that only atypical isoforms play a significant role in complex inflammatory milieus
Wang et al., J Biol Chem 2010 : We examined adhesion restricted signaling pathways that enable IL-1 induced MMP release in human gingival and murine fibroblasts
García-Arnandis et al., Arthritis Res Ther 2010 (MAP Kinase Signaling System...) : In OA synoviocytes, HMGB1 alone at concentrations of 15 or 25 ng/ml did not affect the production of IL-6, IL-8, CCL2, CCL20, MMP-1 or MMP-3, but in the presence of IL-1ß , a significant potentiation of protein and mRNA expression, as well as MMP activity was observed
Zhang et al., Mol Hum Reprod 2011 : Pretreatment of EcSCs with PDTC attenuated IL-1ß induced expressions of CD44s, MMP-2 , MMP-9 and survivin at gene and protein levels
Toegel et al., Genes & nutrition 2012 : We further observed that the levels of IL1ß induced MMP-1, MMP-3 , MMP-7, and MMP-9 mRNA, but not TIMP mRNA levels, were down-regulated in chondrocytes in response to CSE
Akhtar et al., BMC complementary and alternative medicine 2011 (Osteoarthritis) : Effect of HLM on IL-1ß induced gene expression of iNOS, MMP-9 , MMP-13, ACAN and COL2A1 was verified by real time-PCR
Pecchi et al., Osteoarthritis Cartilage 2012 : IL-1ß increased COX-2, mPGES-1, MMP-3 , MMP-13, RANKL expressions, decreased 15-PGDH expression, and increased PGE2, MMP-3 and MMP-13 release ... Interestingly, 7 days of CS treatment significantly counteracted IL-1ß induced expression of COX-2 ( -62 %, P < 0.001 ), mPGES-1 ( -63 %, P < 0.001 ), MMP-3 ( -39 %, P=0.08 ), MMP-13 ( -60 %, P < 0.001 ) and RANKL ( -84 %, P < 0.001 ) ... Accordingly, IL-1ß induced PGE2, MMP-3 and MMP-13 releases were inhibited by 86 % ( P < 0.001 ), 58 % ( P < 0.001 ) and 38 % ( P < 0.01 ) respectively
Ma et al., Arthritis Rheum 2012 (Wnt Signaling Pathway) : The aim of this study was to investigate the role of Wnt/ß-catenin signaling in interleukin-1ß (IL-1ß) induced MMP expression in human chondrocytes ... Wnt/ß-catenin signaling in human chondrocytes had an unexpected anticatabolic role by counteracting NF-?B mediated MMP expression induced by IL-1ß in a negative feedback loop
Kapral et al., Int J Colorectal Dis 2012 (Colonic Neoplasms...) : Stimulation of cells with IL-1ß only resulted in an overexpression of MMP and their TIMP mRNAs ... Proinflammatory cytokine IL-1ß upregulates MMP and TIMP mRNAs expression in colon cancer epithelial cells Caco-2
Zhou et al., Invest Ophthalmol Vis Sci 2012 (Disease Models, Animal) : IL-1ß induced MMP expression and activation as well as collagen degradation were also blocked by the p38 MAPK inhibitor SB203580
Fioravanti et al., J Pharmacol Sci 2012 (Osteoarthritis) : The presence of IL-1ß led to a significant increase in PGE ( 2 ), MMP-3 , and NO production, as well as a significant increase in gene expression of COX-2 and iNOS
Bougault et al., Arthritis Rheum 2012 (Disease Models, Animal...) : LPS, IL-1a , and TNFa dose-dependently increased MMP-3, MMP-9 , and MMP-13 activity in cultured chondrocytes and in NLRP3 ( -/- ) chondrocytes, and this effect was not changed by inhibiting caspase 1 or IL-1ß
Petrella et al., Cancer medicine 2012 : Specifically, IL-1ß induced the expression of MMP-1, MMP-3 , MMP-10, and MT1-MMP in a mechanism dependent on IL-1ß activation of the transcription factor CCAAT enhancer binding protein ß ( CEBPß )
Wei et al., Spine (Phila Pa 1976) 2013 : ERK inhibition reversed the changes of protein expression of MMP-3, MMP-13 , TIMP-1, aggrecan and collagen II induced by IL-1
Rawdanowicz et al., J Clin Endocrinol Metab 1994 : Both interleukin-1 alpha and tumor necrosis factor-alpha stimulated the secretion of MMP-1, MMP-3 , and MMP-9, but not MMP-2, from the cells in a concentration dependent manner
Sato et al., FEBS Lett 1996 : The suppressive effect of IL-1alpha on the TNFalpha induced proMMP-9 production is a new biological effect of IL-1 on MMP production
Kusano et al., Endocrinology 1998 (Bone Resorption) : In mouse calvarial cultures, IL-1 markedly enhanced the messenger RNA ( mRNA ) expression of MMP-13 ( collagenase 3 ), MMP-2 ( gelatinase A ), MMP-9 ( gelatinase B ), and MMP-3 ( stromelysin 1 ), which associated with increases in bone matrix degradation ... In mouse osteoblastic cells, the expression ofMMP-2, MMP-3 , and MMP-13 mRNAs could be detected, and they were markedly enhanced by IL-1alpha on days 2 and 5
Sasaki et al., J Biochem 1998 : IL-1 sequentially stimulated mRNA expression of iNOS, membrane type 1-MMP , MMP-9 and -3, and bFGF, in that order
Andersen et al., Anticancer Res 1998 (Bone Neoplasms...) : The CAPL protein expressed in cell-cultures appear to block the MMP induction by bFGF and Il-1 alpha