Gene interactions and pathways from curated databases and text-mining

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MMP9 — PLD2

Text-mined interactions from Literome

Ho et al., FEBS Lett 2003 (Fibrosarcoma) : These data are in agreement with previous results demonstrating a significant role for PLD in regulating MMP-9 secretion
Lee et al., J Cell Biochem 2004 : Secretions of MMP-9 by soluble glucocorticoid induced tumor necrosis factor receptor ( sGITR ) mediated by protein kinase C (PKC)delta and phospholipase D ( PLD ) in murine macrophage ... Our data indicates that sGITR induced activation of PKCdelta and PLD increases MMP-9 secretions in macrophages
Kato et al., J Biol Chem 2005 (Melanoma, Experimental) : We found that acidic pHe ( 5.9 ) activated phospholipase D ( PLD ), and inhibition of PLD activity by 1-butanol and Myr-ARF6 suppressed the acidic pHe induced MMP-9 expression ... These data suggest that PLD , mitogen activated protein kinases ( extracellular signal regulated kinases 1/2 and p38 ), and NF kappa B mediate the acidic pHe signaling to induce MMP-9 expression