Gene interactions and pathways from curated databases and text-mining

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MSI2 — MUC21

Text-mined interactions from Literome

Hauber et al., J Allergy Clin Immunol 2005 (Chronic Disease...) : Niflumic acid and MSI-2216 reduce TNF-alpha induced mucin expression in human airway mucosa
Hauber et al., J Endotoxin Res 2007 (Inflammation) : We also investigated the effect of NFA and MSI-2216 on LPS induced mucin up-regulation
Hauber et al., Laryngoscope 2008 (Hypersensitivity...) : IL-4, IL-9, and IL-13 significantly increased epithelial mucin expression ( P < .05 ). Dexamethasone reduced Th2 type cytokine induced mucin expression in a dose dependent manner being statistically significant at concentrations > or=4.0 micromol/L ( IL-4 ) and > or=40.0 micromol/L ( IL-9 and IL-13 ) ( P < .05 ). ACC had no significant effect on IL-4 and IL-13 induced mucin expression, whereas IL-9 induced mucin expression was significantly decreased at concentrations > or=3.0 mmol/L ( P < .05 ). NFA and MSI-2216 decreased Th2 type cytokine induced mucin expression in a dose dependent manner. This effect was statistically significant at concentrations > or=100 micromol/L ( NFA ) and > or=50 micromol/L ( MSI-2216 ) ( P < .05 )