Gene interactions and pathways from curated databases and text-mining

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MUC7 — PAF1

Text-mined interactions from Literome

Adler et al., Am J Respir Cell Mol Biol 1992 : The stimulatory effect of PAF on both mucin secretion and formation of HETEs was inhibited by the PAF receptor antagonists, CV-3988 and Ro 19 3704, with Ro 19 3704 acting at a concentration 10-fold lower than CV-3988 in inhibiting both effects
Rieves et al., Am J Respir Cell Mol Biol 1992 : Both NDGA and BPB blocked PAF stimulated mucin release in a concentration dependent manner
Adler et al., Exp Lung Res 1987 : The stimulatory effect of PAF on mucin secretion is blocked by equimolar concentrations of nordihydroguiaretic acid ( NDGA ) a `` mixed '' inhibitor of both cyclo- and lipoxygenase pathways of arachidonic acid metabolism ... In addition, the stimulatory effect of PAF on mucin secretion is not altered by FPL-55712, a receptor antagonist of LTD4 ... These results are consistent with the hypothesis that PAF stimulates secretion of mucin by activating biosynthesis of lipoxygenase products ( e.g., peptidyl leukotrienes ) within epithelial cells of the respiratory mucosa
Sperber et al., Inflamm Bowel Dis 1998 (Colitis, Ulcerative...) : In HT-29 cells, MMS-68 plus leukotriene C4 ( LTC4 ) induced a 50 % increase in mucin release over either secretagogue alone, and MMS-68 plus platelet activating factor (PAF) markedly enhanced mucin release by eightfold over either secretagogue
Lou et al., Am J Respir Crit Care Med 1998 (Asthma...) : In this study, we examined the hypothesis that platelet activating factor (PAF) induces goblet cell hyperplasia and mucin gene expression ... In rat tracheas studied by in situ hybridization, PAF induced mucin MUC5 gene expression in epithelial cells that stained for mucosubstances