Gene interactions and pathways from curated databases and text-mining

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EP300 — MYC

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Faiola et al., Mol Cell Biol 2005 : In addition, p300 functions as a coactivator that is recruited by Myc to the promoter of the human telomerase reverse transcriptase gene, and p300/CBP stimulates Myc TAD dependent transcription in a HAT domain dependent manner ... Our results suggest dual roles for p300/CBP in Myc regulation : as a Myc coactivator that stabilizes Myc and as an inducer of Myc instability via direct Myc acetylation
Singhal et al., Virology 2008 : We previously showed that in quiescent cells p300/CBP negatively regulates the cell cycle G1-S transition by keeping c-Myc in a repressed state and that adenovirus E1A induces c-Myc by binding to p300/CBP