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IL6 — MYC

Text-mined interactions from Literome

Shamsasenjan et al., Int J Hematol 2009 (Multiple Myeloma) : IL-6 induced activation of MYC is responsible for the down-regulation of CD33 expression in CD33+ myeloma cells ... Furthermore, IL-6 up-regulated the expression of MYC via STAT3 phosphorylation and MYC bound to the promoter region of the CEBPA gene followed by the down-regulation of CEBPA expression
Shi et al., J Biol Chem 2011 (Multiple Myeloma) : Prior work indicates that IL-6 can stimulate c-Myc expression in multiple myeloma ( MM ) cells, which is independent of effects on transcription and due to enhanced translation mediated by an internal ribosome entry site in the 5'-UTR of the c-Myc RNA