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MYD88 — TRAF6

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: O/k complex () → Complex of MYD88-TLR4-TRAF6 (increases, MYD88/TLR4/TRAF6 Activity)
  Lee et al., J Biol Chem 2003*
  Evidence: MyD88 is known as an immediate downstream adaptor molecules that interacts directly with TIR domain of TLRs. MyD88 recruits Il1 receptor-associated kinase (Irak) and Traf6 leading to activation of NFkB and MAPKs.
• BioCarta toll-like receptor pathway: TLR2/TLR6 activating compounds/TLR2/TLR6/MYD88/IRAK/CD14 complex (CD14-TLR6-TLR2-MYD88-IRAK1) → TRAF6 (modification, activates)
• BioCarta nf-kb signaling pathway: LPS/TLR4/TLR4/MYD88/IRAK/TRAF6 complex (TLR4-MYD88-IRAK1-TRAF6) → IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4) (modification, activates)
  
• BioCarta toll-like receptor pathway: Imiquimod/TLR7/TLR7/MYD88/IRAK complex (MYD88-TLR7-IRAK1) → TRAF6 (modification, activates)
• BioCarta toll-like receptor pathway: Poly (I:c)TLR3/TLR3/MYD88/IRAK complex (IRAK1-MYD88-TLR3) → TRAF6 (modification, activates)
• BioCarta nf-kb signaling pathway: IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6) → IL-1-alpha (IL1A) (modification, collaborate)
• BioCarta nf-kb signaling pathway: IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6) → IL-1R/MYD88/IRAK/TRAF6 complex (IL1R1-MYD88-IRAK1-TRAF6) (modification, collaborate)
  
• BioCarta nf-kb signaling pathway: IL-1-alpha (IL1A) → IL-1R/MYD88/IRAK/TRAF6 complex (IL1R1-MYD88-IRAK1-TRAF6) (modification, collaborate)
  
• BioCarta toll-like receptor pathway: CpG DNA/TLR9/TLR9/MYD88/IRAK complex (IRAK1-TLR9-MYD88) → TRAF6 (modification, activates)
• BioCarta toll-like receptor pathway: TLR2/TLR6 activating compounds/TLR2/TLR2/MYD88/IRAK/CD14 complex (MYD88-IRAK1-CD14-TLR2) → TRAF6 (modification, activates)
• BioCarta signal transduction through il1r: IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → TRAF6 (modification, activates)
• BioCarta nf-kb signaling pathway: IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6) → TAB1/TAK1 complex (MAP3K7IP1-MAP3K7) (modification, activates)
  
• BioCarta nf-kb signaling pathway: IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6) → IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4) (modification, activates)
  
• BioCarta toll-like receptor pathway: LPS/TLR4/TLR4/TIRAP/TOLLIP/PKR/MYD88/IRAK/MD-2/CD14 complex (EIF2AK2-MYD88-CD14-TLR4-TOLLIP-TIRAP-IRAK1-LY96) → TRAF6 (modification, activates)
• BioCarta nf-kb signaling pathway: TLR4/TLR4/MYD88/IRAK/TRAF6 complex (TLR4-MYD88-IRAK1-TRAF6) (modification, collaborate)
• BioCarta nf-kb signaling pathway: TLR4/TLR4/MYD88/IRAK/TRAF6 complex (TLR4-MYD88-IRAK1-TRAF6) → LPS/TLR4/TLR4/MYD88/IRAK/TRAF6 complex (TLR4-MYD88-IRAK1-TRAF6) (modification, collaborate)
  
• BioCarta nf-kb signaling pathway: None → LPS/TLR4/TLR4/MYD88/IRAK/TRAF6 complex (TLR4-MYD88-IRAK1-TRAF6) (modification, collaborate)
  
• KEGG Toll-like receptor signaling pathway: Complex of MYD88-TIRAP → TRAF6 (protein-protein, activation)
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → TRAF6 (TRAF6) (modification, collaborate) Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6 complex (IRAK1-TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database p75(NTR)-mediated signaling: MYD88 (MYD88) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK complex (NGF-NGFR-TRAF6-RIPK2-IRAK1) (modification, activates)
  Mamidipudi et al., J Biol Chem 2002
  Evidence: physical interaction, other species
• NCI Pathway Database p75(NTR)-mediated signaling: MYD88 (MYD88) → NGF (dimer)/p75(NTR)/TRAF6/RIP2 complex (NGF-NGFR-TRAF6-RIPK2) (modification, activates)
  Mamidipudi et al., J Biol Chem 2002
  Evidence: physical interaction, other species
• Reactome Reaction: MYD88 → TRAF6 (reaction) Ross et al., J Biol Chem 2002, Ye et al., Nature 2002, Kollewe et al., J Biol Chem 2004, Kawai et al., Nat Immunol 2004, Gottipati et al., Cell Signal 2008, Muroi et al., J Leukoc Biol 2008, Ning et al., Mol Cell Biol 2008, Cao et al., Nature 1996, Burns et al., J Biol Chem 1998*, Khursigara et al., J Biol Chem 1999
• Reactome Reaction: MYD88 → TRAF6 (indirect_complex) Ross et al., J Biol Chem 2002, Ye et al., Nature 2002, Muroi et al., J Leukoc Biol 2008, Cao et al., Nature 1996, Khursigara et al., J Biol Chem 1999
• WikiPathways Structural Pathway of Interleukin 1 (IL-1): MYD88 → TRAF6 (unknown)
• WikiPathways TLR4 Signaling and Tolerance: Complex of IRAK1-MYD88-IRAK4 → TRAF6 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TRAF6 — MYD88 (physical association, affinity chromatography technology) Zhou et al., Proc Natl Acad Sci U S A 2011*
• IRef Biogrid Interaction: TRAF6 — MYD88 (physical association, affinity chromatography technology) Zhang et al., Cell Res 2013*
• IRef Biogrid Interaction: TRAF6 — MYD88 (physical association, affinity chromatography technology) Hirata et al., J Immunol 2006*
• Gene Ontology Complexes protein complex: protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3) Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
• IRef Hprd Interaction: Complex of 65 proteins (in vivo) Tseng et al., Nat Immunol 2010
• IRef Hprd Interaction: Complex of 82 proteins (in vivo) Tseng et al., Nat Immunol 2010
• IRef Intact Interaction: Complex of 13 proteins (association, pull down) He et al., Nat Immunol 2010
• IRef Intact Interaction: Complex of TNFRSF13B-TRAF6-MYD88 (colocalization, confocal microscopy) He et al., Nat Immunol 2010

Text-mined interactions from Literome

Selvarajoo et al., PloS one 2008 : Investigating another TLR4 pathway junction, from TRIF to TRAF6, RIP1 and TBK1, the removal of MyD88 dependent TRAF6 increased expression of TRAM dependent Cxcl10 and Ifit2
Kar et al., Eur J Immunol 2011 (Inflammation...) : Analysis of upstream signaling events revealed that TLR 2/4 mediated MyD88 dependent participation of IL-1R activated kinase (IRAK)1, TNF receptor associated factor (TRAF)6 and TGFß activated kinase (TAK)1 is essential to induce cystatin mediated I?B kinase ( IKK ) /NF-?B activation in macrophages
Kitagawa et al., J Virol 2013 : These results demonstrate that binding of the V protein to IRF7, IKKa, and MyD88 is largely indirect and mediated by endogenous TRAF6