Gene interactions and pathways from curated databases and text-mining

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AKT3 — NEUROD4

Text-mined interactions from Literome

Bang et al., J Cell Sci 2001 : Overexpression of Akt inhibits NGF induced growth arrest and neuronal differentiation of PC12 cells ... To investigate the role of Akt in nerve growth factor (NGF) induced neuronal differentiation , PC12 cells ectopically expressing wild-type or dominant-inhibitory forms of Akt were analyzed
Taraviras et al., Eur J Cell Biol 2002 (MAP Kinase Signaling System) : Epinephrine induced neuronal differentiation of PC12alpha2 cells through alpha2-AR activation in a subtype dependent manner, internalization of all human alpha2-AR subtypes, and activation of mitogen activated protein kinase ( MAPK ) and the serine-threonine protein kinase Akt
Oishi et al., Proc Natl Acad Sci U S A 2009 : Furthermore, active Akt increased the protein levels and transactivation activity of Mash1, a proneural basic helix-loop-helix protein required for the generation of neocortical GABAergic neurons, and Mash1 was required for Akt induced neuronal differentiation
Park et al., BMB Rep 2012 : However, the exact role of Akt in neuronal differentiation is still controversial
Noh et al., Mol Biol (Mosk) 2012 : Furthermore, NAC enhanced neuronal differentiation was mediated by activation of Akt
Zhang et al., Neural development 2013 : AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development ... These results show that N-cadherin regulates ß-catenin signaling through both Wnt and AKT, and suggest a previously unrecognized role for AKT in neuronal differentiation and cell survival during cortical development