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NOS3 — ROCK1

Text-mined interactions from Literome

Ming et al., Mol Cell Biol 2002 : Using adenovirus mediated gene transfer in human umbilical vein endothelial cells ( HUVECs ), we show here that both active RhoA and ROCK not only downregulate eNOS gene expression as reported previously but also inhibit eNOS phosphorylation at Ser-1177 and cellular NO production with concomitant suppression of PKB activation
Barandier et al., Biochem Biophys Res Commun 2003 : We showed that expression of constitutively active RhoA ( Rho63 ) or ROCK ( CAT ) suppressed eNOS gene expression ... Similarly, suppression of eNOS expression and activation of ROCK , but not RhoA by thrombin were prevented by PKC inhibition or depletion
Zhou et al., Curr Pharm Des 2009 (Atherosclerosis...) : While increased ROCK activity is associated with endothelial dysfunction, cerebral ischemia, coronary vasospasms and metabolic syndrome, the inhibition of ROCK by statins or selective ROCK inhibitors leads to up-regulation of endothelial nitric oxide synthase (eNOS) , decreased vascular inflammation, and reduced atherosclerotic plaque formation
Hassona et al., Am J Physiol Heart Circ Physiol 2010 (Disease Models, Animal...) : The activation of Rho/ROCK led to the inhibition of endothelial nitric oxide synthase expression ( 39 + or - 5.4 % ; P < 0.05 ) and phosphorylation ( 35 + or - 4.5 % ; P < 0.05 ) but also an increase in myosin light chain 20 phosphorylation ( 372 %, P < 0.05 )
Li et al., Zhonghua Xin Xue Guan Bing Za Zhi 2011 (Hypertension, Pulmonary) : Rosuvastatin also inhibited PCNA expression of SMC ( P < 0.01 ), restored eNOS expression of EC ( P < 0.05 ) and inhibited ROCK-1 mRNA expressions in lung tissue ( P < 0.05 )
Ramseyer et al., Hypertension 2012 : Inhibition of ROCK with 10 µmol/L of H-1152 blocked TNF-a induced decreases in NOS3 expression by 66 ± 15 % ( P < 0.001 )