Gene interactions and pathways from curated databases and text-mining

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NOX3 — RELA

Text-mined interactions from Literome

Bonizzi et al., Mol Cell Biol 1999 (Adenocarcinoma) : Reactive oxygen intermediate dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity
Yoshida et al., J Immunol 2001 : Inhibition of NADPH oxidase suppressed NF-kappaB binding by nuclear extracts and decreased production of MMP-2 and 9 in AMs from SP-D ( -/- ) mice
Brar et al., Am J Physiol Lung Cell Mol Physiol 2002 : NADPH oxidase promotes NF-kappaB activation and proliferation in human airway smooth muscle ... Inhibition of NADPH oxidase activity with DPI prevented serum induced activation of nuclear factor-kappaB (NF-kappaB) , and overexpression of a superrepressor form of the NF-kappaB inhibitor IkappaBalpha significantly reduced human AWSM growth
Aramaki et al., Biol Pharm Bull 2002 : These results indicated that NADPH-oxidase plays a crucial role in macrophage activation by CpG-ODN and NF-kappaB does not act as a predominant transcription factor for IL-12 secretion
Fass et al., Brain Res 2004 : To determine whether different types of NO donors exert differential toxicity in a cholinergic neuronal model, we measured cell viability markers, indicators of NOx formation, levels of intracellular reduced glutathione ( GSH ), protein nitrosothiols, and the activation of the transcription factor NF-kappaB in a mouse medial septal cholinergic cell line ( clone SN56 ) following exposure to the NO donors S-nitroso-N-acetyl-dl-penicillamine ( SNAP ), 3-morpholinosydnonimine ( SIN-1 ), or sodium nitroprusside ( SNP )
Yamagishi et al., J Mol Cell Cardiol 2004 : The results demonstrated that PEDF inhibited TNF-alpha induced NF-kappaB activation and subsequent IL-6 overexpression in HUVEC by suppressing NADPH oxidase mediated ROS generation
Beak et al., Biochimie 2004 : These results suggest that the NADPH oxidase and COX may be major sources for the UVB induced ROS generation, and play an essential role in the activation of NF-kappaB which is involved in the expression of a variety of genes induced by UVB in HaCaT cells
Yu et al., Int J Biochem Cell Biol 2005 : NADPH oxidase inhibitor diphenylene iodonium ( DPI ), antioxidant rebamipide, and antisense oligonucleotides ( AS ODNs ) for NADPH oxidase subunits p22phox and p47phox were used to determine the involvement of NADPH oxidase in NF-kappaB activation and IL-6 expression in AR42J cells
Anrather et al., J Biol Chem 2006 : NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox
Frey et al., J Biol Chem 2006 : Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase mediated oxidant generation and NF-kappaB activation in endothelial cells ... Thus, PI3Kgamma lies upstream of PKCzeta in the endothelium, and its activation is crucial in signaling NADPH oxidase dependent oxidant production and subsequent NF-kappaB activation and ICAM-1 expression
LemariƩ et al., Circ Res 2006 : Here we report that high intraluminal pressure induces reactive oxygen species ( ROS ) in arteries and that inhibition of NADPH oxidase prevents both the generation of ROS and the activation of NF-kappaB associated with high pressure
Takenaka et al., J Mol Cell Cardiol 2006 (Heart Failure...) : Local activation of Ang-II in hypertrophic LV triggers MMP mediated ECM degradation, namely LV remodeling, at least in part, through NADPH oxidase induced oxidative stress and the subsequent NFkappaB activation
Jo et al., Antioxid Redox Signal 2006 (Atherosclerosis...) : The NADPH oxidase activation by BMP4 then leads to ROS production, NF-kappaB activation, intercellular adhesion molecule 1 ( ICAM-1 ) expression, and subsequent increased monocyte adhesivity of endothelial cells
Dasu et al., Am J Physiol Endocrinol Metab 2007 (MAP Kinase Signaling System) : At the same time, it appears that NADPH oxidase via p47phox activates NF-kappaB , resulting in increased IL-1beta secretion
Gauss et al., J Leukoc Biol 2007 : Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alpha
Carluccio et al., Am J Physiol Heart Circ Physiol 2007 (Hyperhomocysteinemia) : Homocysteine induces VCAM-1 gene expression through NF-kappaB and NAD ( P ) H oxidase activation : protective role of Mediterranean diet polyphenolic antioxidants
Chan et al., J Pharmacol Exp Ther 2007 (Acute Disease...) : These data provide substantial evidence that angiotensin II is involved in AT1 receptor mediated NADPH oxidase dependent NF-kappaB activation ; thus, it might ultimately promote proinflammatory actions during AP pathogenesis
Vaziri et al., J Pharmacol Exp Ther 2007 (Disease Models, Animal...) : The untreated group exhibited hypertension, deterioration of renal function and structure, reduced or unchanged plasma renin activity, aldosterone concentration, marked up-regulations of AT1r ( 250 % ), Ang II-expressing cell count ( > 20-fold ), NAD ( P ) H oxidase subunits ( gp91(phox,) p22(phox), and P47 ( phox ) ; 20-40 % ), COX-2 ( 250 % ), 12-lipooxygenase ( 100 % ), MCP-1 ( 400 % ), and PAI-1 ( > 20-fold ), activation of NFkappaB , and interstitial infiltrations of T cells and macrophages in the remnant kidneys
Kim et al., J Ethnopharmacol 2007 : Furthermore, macrophages stimulated with LPS generated ROS via activation of membrane bound NADPH oxidase , and ROS played an important role in the activation of nuclear factor-kappaB (NF-kappaB) and MAPKs
Wei et al., Am J Physiol Endocrinol Metab 2008 (Insulin Resistance) : Angiotensin II-induced skeletal muscle insulin resistance mediated by NF-kappaB activation via NADPH oxidase
Manea et al., Arch Physiol Biochem 2007 : Here we investigate the role of NF-kB in the regulation of p22(phox) subunit and NADPH oxidase activity, in human aortic smooth muscle cells ... Regulation of NADPH oxidase by NF-kB may represent a possible mechanism whereby pro-inflammatory factors induce oxidative stress in atherosclerosis, hypertension, diabetes, stroke or heart failure
Luengo-Blanco et al., Blood 2008 (Ectodermal Dysplasia...) : This work investigated the functional role of nuclear factor-kappaB (NF-kappaB) in respiratory burst activity and in expression of the human phagocyte nicotinamide adenine dinucleotide phosphate ( NADPH ) oxidase genes CYBB, CYBA, NCF1, and NCF2 ... These studies show that NF-kappaB is necessary for CYBB and NCF1 gene expression and activation of the phagocyte NADPH oxidase in this model system
Guo et al., Antioxid Redox Signal 2008 (MAP Kinase Signaling System...) : Incubation of AOPPs, either prepared in vitro or isolated from uremic serum, with human umbilical vein ECs induced superoxide generation, activation of NAD ( P ) H oxidase , ERK 1/2 and p38, and nuclear translocation of NF-kappaB
Collins-Underwood et al., Free Radic Biol Med 2008 : Pharmacologic and genetic inhibition of NADPH oxidase blocked the radiation mediated upregulation of intracellular ROS, activation of NFkappaB , and upregulation of ICAM-1 and PAI-1
Bai et al., Am J Nephrol 2009 (Kidney Failure, Chronic...) : Voluntary exercise reversed NF-kappaB activation and lowered NAD ( P ) H oxidase , PAI-1, MCP-1 and COX-2 abundance, increased LV mass by raising myofibrillar proteins and ameliorated anemia without affecting renal function or arterial pressure
Zhang et al., Invest Ophthalmol Vis Sci 2009 (Diabetes Mellitus, Experimental...) : Analysis of downstream signals showed that inhibition of NAD ( P ) H oxidase partially inhibited NF-kappaB activation but did not reduce CCL2 mRNA stability or prevent TNF-alpha induced phosphorylation of p38MAPK
Cho et al., American journal of physiology. Renal physiology 2009 (Disease Models, Animal...) : The untreated CKD rats exhibited azotemia, hypertension, hypertriglyceridemia, proteinuria, glomerulosclerosis, tubulointerstitial damage, upregulation of MCP-1, plasminogen activator inhibitor-1 ( PAI-1 ), transforming growth factor ( TGF ) -beta, cyclooxygenase (COX)-1, COX-2, and NAD ( P ) H oxidase ( NOX-4, gp91(phox), p47(phox) and p22(phox) subunits ) and activation of NF-kappaB ( IkappaB phosphorylation )
Pan et al., Braz J Med Biol Res 2009 (Inflammation) : These data suggest that the inhibition of NAD ( P ) H oxidase dependent NF-kappaB signaling reduces the increase in MCP-1 production by GECs induced by Ang II
Maloney et al., Arterioscler Thromb Vasc Biol 2009 : Activation of NF-kappaB by palmitate in endothelial cells : a key role for NADPH oxidase derived superoxide in response to TLR4 activation
Kim et al., American journal of physiology. Renal physiology 2010 (Disease Models, Animal...) : In confirmation of earlier studies, rats with chronic renal failure exhibited increased lipid peroxidation, glutathione depletion, NF-kappaB activation , mononuclear cell infiltration, and upregulation of monocyte chemoattractant protein-1, NAD ( P ) H oxidase , cyclooxygenase-2, and 12-lipoxygenase in the remnant kidney pointing to oxidative stress and inflammation
Wang et al., Circ Res 2010 : Consistently, we found that genetic deletion of AMPKalpha2 in low-density lipoprotein receptor knockout ( LDLr ( -/- ) ) strain markedly increased 26S proteasome activity, IkappaB degradation, NF-kappaB transactivation , NAD ( P ) H oxidase subunit overexpression, oxidative stress, and endothelial dysfunction, all of which were largely suppressed by chronic administration of MG132, a potent cell permeable proteasome inhibitor
Heo et al., Vascul Pharmacol 2010 (Atherosclerosis) : Furthermore, the NADPH oxidase assembly inhibitor, AEBSF, and the blocker of NADPH oxidase, p47(phox) small interference RNA ( siRNA ), also efficiently blocked LIGHT induced migration, CCR1, CCR2, ICAM-1, and HVEM expression, and p38 MAPK and NF-kB activation
Salzman et al., Gastroenterology 1998 (Salmonella Infections) : In DLD-1 cells, S. dublin mediated NOx was blocked by inhibitors of nuclear factor kappa B (NF-kappa B) and tyrosine kinase activation and was steroid resistant