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IGF1 — NOX4

Text-mined interactions from Literome

Tsukamoto et al., J Neurosci Res 2003 (Alzheimer Disease) : Further investigation suggested that Abeta neurotoxicity via p75NTR involved JNK, NADPH oxidase , and caspases-9/3 and was inhibited by activity dependent neurotrophic factor, insulin-like growth factor-I , basic fibroblast growth factor, and Humanin, as observed in primary neuron cultures
Meng et al., Cardiovasc Res 2008 : Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells
Edderkaoui et al., J Biol Chem 2011 (Pancreatic Neoplasms) : Here we investigate the mechanisms through which insulin-like growth factor I and serum ( FBS ) activate NADPH oxidase in pancreatic cancer ( PaCa ) cells ... Insulin-like growth factor I and FBS activate NADPH oxidase through transcriptional up-regulation of p22(phox)
Handayaningsih et al., Endocrinology 2011 : Nox4 knockdown, which is reportedly to produce ROS in insulin signaling, attenuated IGF-I induced IGF-IR phosphorylation, indicating that Nox4 is involved in the regulation of IGF-I signaling
New et al., Am J Physiol Cell Physiol 2012 : Expression of dominant negative adenovirus Nox4 inhibits IGF-I induced NADPH oxidase activity, Akt phosphorylation, and fibronectin protein expression
Xi et al., Diabetes 2012 (Hyperglycemia) : Hyperglycemia induced Nox4 , but not Nox1, and p22 phagocyte oxidase (p22phox) expression and IGF-I stimulated Nox4/p22phox complex formation, leading to increased ROS generation